BJA Advance Access originally published online on January 8, 2007
British Journal of Anaesthesia 2007 98(2):236-240; doi:10.1093/bja/ael340
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Asynchronous administration of xenon and hypothermia significantly reduces brain infarction in the neonatal rat
1 Department of Anaesthetics, Pain Medicine, and Intensive Care
2 Biophysics Section, The Blackett Laboratory, Imperial College London, London SW7 2AZ, UK
* Corresponding author: Department of Anaesthesia, Chelsea & Westminster Hospital, Imperial College London, 369, Fulham Road, London SW10 9NH, UK. E-mail: d.ma{at}imperial.ac.uk
BACKGROUND: Neonatal asphyxia causes long-term neurological and behavioural impairment in the developing brain. Concurrent administration of xenon and hypothermia synergistically reduces long-term damage in a rat model of neonatal asphyxia. This study sought to investigate whether asynchronous administration of xenon and hypothermia is capable of combining synergistically to provide neuroprotection.
METHODS: Seven-day-old rats were subjected to right common carotid artery occlusion followed by 90 min hypoxia with 8% oxygen. After a 1 h recovery period, rats received asynchronous administration of mild hypothermia (35°C) and xenon (20%) with a 1 or 5 h gap between interventions, xenon (20%) alone, or mild hypothermia (35°C) alone. Infarct volume in the brain was measured 4 days after injury.
RESULTS: Administration of hypothermia or xenon alone, 1 and 6 h after the hypoxic ischaemic insult, respectively, provided no neuroprotection. Asynchronous administration of xenon and hypothermia at a 1 h interval produced a significant reduction in infarct volume [93 (7) vs 74 (8); P < 0.05]. Reduction in infarct volume was also present when hypothermia and xenon were asynchronously administered with an intervening gap of 5 h [97 (5) vs 83 (3); P < 0.05].
CONCLUSIONS: This finding provides a rationale for investigating the combined use of hypothermia and xenon in a progressive manner for the management of neonatal asphyxia. Thus, hypothermia can be administrated at the site of delivery and xenon can be administered later.
Keywords: anaesthetics gases, xenon; hypothermia, asynchronous; hypoxia-ischaemia; neonate; rat
Declaration of interest. Professors Maze and Franks are paid consultants to Air Products, a company that is interested in developing clinical applications for medical gases, including xenon. In addition, Air Products have funded, and continue to fund, work in the authors' laboratories that bears on the actions of xenon as an anaesthetic and neuroprotectant.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Hobbs, M. Thoresen, A. Tucker, K. Aquilina, E. Chakkarapani, and J. Dingley Xenon and Hypothermia Combine Additively, Offering Long-Term Functional and Histopathologic Neuroprotection After Neonatal Hypoxia/Ischemia Stroke, April 1, 2008; 39(4): 1307 - 1313. [Abstract] [Full Text] [PDF]
|
|