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BJA Advance Access originally published online on June 17, 2006
British Journal of Anaesthesia 2006 97(2):220-225; doi:10.1093/bja/ael144
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

The effect of melatonin on sedation of children undergoing magnetic resonance imaging

M. R. J. Sury1,3,* and K. Fairweather2,3

1 Department of Anaesthesia, Great Ormond Street Hospital for Children NHS Trust London WC1N 3JH, UK
2 Department of Radiology, Great Ormond Street Hospital for Children NHS Trust London WC1N 3JH, UK
3 Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, Institute of Child Health 30 Guilford Street, London WC1N 1EH, UK

*Corresponding author. E-mail: surym{at}gosh.nhs.uk

Background. Melatonin may induce a natural sleepiness and improve predictability of sedation drugs. We have investigated its clinical value in children sedated for magnetic resonance imaging.

Methods. In a stratified randomized double-blind study, 98 children received either melatonin or placebo 10 min before they were sedated with a standard oral regimen. Children >5 and <15 kg received chloral hydrate and those ≥15 and <40 kg had a combination of temazepam with droperidol (T&D). The doses of melatonin were 3 and 6 mg, respectively. One observer recorded the time taken to reach criteria for deep sedation, sedation failure and other sedation-related events.

Results. In the chloral hydrate group (n=50) 50% were deeply sedated by 31 min after melatonin and 40 min after placebo (P=0.57). There were zero and 1 failures, respectively. The geometric mean time taken to reach deep sedation was 39 min in both subgroups. In the T&D group (n=48) 50% were deeply sedated by 70 min in both subgroups (two failures in each); geometric mean times were 68 and 71 min, respectively (P=0.58). Children closed their eyes slightly earlier after melatonin (respective geometric means 42 vs 48, P=0.17), and took slightly longer to achieve discharge criteria (146 vs 135, P=0.47).

Conclusion. In these doses and clinical conditions, melatonin did not contribute to sedation of children.


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This article has been cited by other articles:


Home page
 Br J AnaesthHome page
O. Dearlove and J.P. Corcoran
Sedation of children undergoing magnetic resonance imaging
Br. J. Anaesth., April 1, 2007; 98(4): 548 - 549.
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 Br J AnaesthHome page
J. G. Allen and M. R. J. Sury
Sedation of children undergoing magnetic resonance imaging.
Br. J. Anaesth., December 1, 2006; 97(6): 898 - 899.
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E-letters:

Read all E-letters

Melatonin does not override natural alerting mechanisms...
James M. Howard
British Journal of Anaesthesia, 21 Jun 2006 [Full text]
Paediatric Magnetic Resonance Imaging Under Sedation
Jonathan G Allen
British Journal of Anaesthesia, 22 Aug 2006 [Full text]
Dr Sury's response to the points raised by Dr Allen.
Mike Sury
British Journal of Anaesthesia, 11 Sep 2006 [Full text]
Correspondance
Pooja Ajit Warty
British Journal of Anaesthesia, 4 Oct 2006 [Full text]
Magnetic Resonance Imaging and sedation of children
Antony STEPHEN LAURENCE
British Journal of Anaesthesia, 15 Dec 2006 [Full text]
Further results of sedation for MRI scanning of children
Oliver R Dearlove, et al.
British Journal of Anaesthesia, 4 Jan 2007 [Full text]

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