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BJA Advance Access originally published online on March 10, 2006
British Journal of Anaesthesia 2006 96(5):597-601; doi:10.1093/bja/ael046
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Ketamine, but not propofol, anaesthesia is regulated by metabotropic glutamate 5 receptors

J.-H. Sou1,2, M.-H. Chan1 and H.-H. Chen1,*

1 Institute of Pharmacology and Toxicology, Tzu Chi University Hualien, Taiwan, R.O.C
2 Department of Health, Yuli Hospital Executive Yuan, Hualien, Taiwan, R.O.C.

*Corresponding author: Institute of Pharmacology and Toxicology, Tzu Chi University, 701, Section 3, Chung-Yang Road, Hualien, 970, Taiwan, R.O.C. E-mail: hwei{at}mail.tcu.edu.tw

Background. Group I metabotropic glutamate receptors (mGluRs) have been reported to regulate N-methyl-D-aspartate (NMDA) receptor function in various brain regions. The selective mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) can potentiate NMDA antagonists such as PCP and MK-801-induced behavioural responses. In the present study, the role of group I mGluRs on ketamine- and propofol-induced general anaesthesia was examined.

Methods. Mice were pretreated with various doses of the group I mGluR agonist (S)-3,5-dihydroxyphenylglycine (DHPG), selective mGluR5 agonist (RS)-2-chloro-5-hydroxyphenylglycine (CHPG), mGluR1 antagonist 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester (CPCCOEt) and mGluR5 antagonist MPEP followed by administration of ketamine (120 mg kg–1) or propofol (140 mg kg–1) to induce anaesthesia. The duration of loss of righting reflex was recorded.

Results. DHPG and CHPG antagonized and MPEP potentiated ketamine-induced anaesthesia in a dose-dependent manner. CPCCOEt was ineffective. However, propofol-induced anaesthesia was not affected after manipulating mGluR1 and mGluR5 receptors.

Conclusions. mGluR5 receptors play an important role in modulation of anaesthesia induced by ketamine, but not propofol.


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