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BJA Advance Access originally published online on January 16, 2006
British Journal of Anaesthesia 2006 96(3):310-316; doi:10.1093/bja/ael002
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Adenosine-induced cardiac arrest and EEG changes in patients with thoracic aorta endovascular repair

K. Plaschke1,*, D. Boeckler2, H. Schumacher2, E. Martin1 and H. J. Bardenheuer1

1 Clinic of Anaesthesiology and 2 Department of Vascular and Endovascular Surgery, University of Heidelberg, Germany

* Corresponding author: Clinic of Anaesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, D-69120 Heidelberg, Germany. E-mail: konstanze.plaschke{at}med.uni-heidelberg.de

Background. We studied haemodynamic and metabolic variables, and cerebral function after cardiac arrest induced by high dose of adenosine in patients undergoing thoracic aorta endovascular repair.

Methods. Arterial blood pressure, blood gas values and EEG were recorded continuously in 15 patients undergoing anaesthesia (isoflurane) for endovascular thoracic aorta repair. Cardiac arrest was induced by different doses of adenosine (Adrekar®, Sanofi-Synthelabo, Berlin, Germany; 0.4–1.8 mg kg–1 body weight). Serum concentrations of neurone-specific enolase (NSE) were determined before and after stent graft implantation. Neurological function was assessed before and after surgery.

Results. After adenosine, the heart beat stopped immediately for 18–58 s in close relation to the adenosine dose. EEG power was significantly reduced to –57%, but reached normal values within 5 min after cardiac arrest. In particular, the fast alpha- and beta-EEG-frequencies sensitively reflected patients' EEG activity during the procedure. No intraoperative increases in NSE concentrations, and no neurological dysfunctions after surgery, were observed.

Conclusion. After adenosine-induced cardiac arrest, changes in haemodynamic variables and EEG power spectra reversed completely within 1 and 5 min, respectively, without persistent brain dysfunction after stent graft implantation.


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Erratum

BJA 2006 96: 545. [Extract] [Full Text]  





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