BJA Advance Access originally published online on October 14, 2005
British Journal of Anaesthesia 2005 95(6):811-815; doi:10.1093/bja/aei260
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OBSTETRIC ANAESTHESIA |
Analgesic and antacid properties of i.m. tramadol given before Caesarean section under general anaesthesia
Department of Anaesthesia, Faculty of Medicine, Ain-Sham University, Cairo, Egypt
* Corresponding author. E-mail: mokhtar.elhakim{at}gmail.com
Background. Intramuscular (i.m.) tramadol increases gastric pH during anaesthesia similar to famotidine. We investigated the antacid analgesic value of a single dose of i.m. tramadol given 1 h before elective Caesarean section performed under general anaesthesia.
Methods. Sixty ASA I parturients undergoing elective Caesarean section were included in a randomized double-blind study. The patients were randomly allocated to receive i.m. tramadol 100 mg (n=30) or famotidine 20 mg (n=30) 1 h before general anaesthesia.
Results. At the beginning and the end of anaesthesia, patients receiving tramadol had a median gastric fluid pH of 6.4, which was not significantly different from those treated with famotidine (median 6.3). The infant well-being, as judged by Apgar score, cord blood gas analysis, and neurobehavioural assessment showed no significant difference between the two groups. Nalbuphine consumption in the first 24 h after operation was reduced by 35% in the tramadol group. Pain intensity score on sitting and sedation were significantly greater in famotidine group up to 24 h after surgery. There was no significant difference in incidence and severity of nausea and vomiting between the two groups.
Conclusion. A single i.m. dose of tramadol is useful pre-treatment to minimize the risk of acid aspiration during operation, and in improving pain relief during 24 h after surgery.
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