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BJA Advance Access originally published online on February 11, 2005
British Journal of Anaesthesia 2005 94(5):592-595; doi:10.1093/bja/aei094
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2005. All rights reserved. For Permissions, please e-mail: journal.permissions{at}oupjournals.org

CASE REPORT

Recombinant factor VIIa for life-threatening post-partum haemorrhage{dagger}

J. Ahonen* and R. Jokela

Department of Anaesthesia and Intensive Care, Helsinki University Hospital, Finland

* Corresponding author. E-mail: jouni.ahonen{at}fimnet.fi

The treatment of life-threatening post-partum haemorrhage (PPH) still remains challenging, and hysterectomy may be required to control the bleeding. We present 12 cases of severe PPH treated with recombinant factor VIIa (rFVIIa). We briefly describe the causes of the haemorrhage and the medical and surgical interventions before rVIIa administration. In 11 women there was a partial or good response to rFVIIa administration, while in one there was no response. In the four women undergoing a subsequent selective arterial embolization, the bleeding was significantly reduced although not completely stopped. From our experience with these 12 cases, and from previously reported cases, the use of rFVIIa may be of benefit in life-threatening PPH. However, treatment with rFVIIa, in addition to standard surgical and medical interventions, may not be definitive in every patient and a selective arterial embolization may be needed.

{dagger} This article is accompanied by the Editorial.


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