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BJA Advance Access originally published online on February 18, 2005
British Journal of Anaesthesia 2005 94(5):556-562; doi:10.1093/bja/aei093
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2005. All rights reserved. For Permissions, please e-mail: journal.permissions{at}oupjournals.org

Potential value of adenosine 5'-triphosphate (ATP) and adenosine in anaesthesia and intensive care medicine

A. T. P. Skrabanja1,*, E. A. C. Bouman2 and P. C. Dagnelie1

1 Department of Epidemiology, NUTRIM, Maastricht University, Maastricht, The Netherlands. 2 Department of Anaesthesiology, University Hospital Maastricht, The Netherlands

* Corresponding author. E-mail: arno.skrabanja{at}epid.unimaas.nl

Extracellular adenosine and adenosine triphosphate (ATP) are involved in biological processes including neurotransmission, muscle contraction, cardiac function, platelet function, vasodilatation, signal transduction and secretion in a variety of cell types. They are released from the cytoplasm of several cell types and interact with specific purinergic receptors which are present on the surface of many cells. This review summarizes the evidence on the potential value and applicability of ATP (not restricted to ATP–MgCl2) and adenosine in the field of anaesthesia and intensive care medicine. It focuses, in particular, on evidence and roles in treatment of acute and chronic pain and in sepsis. Based on the evidence from animal and clinical studies performed during the last 20 years, ATP could provide a valuable addition to the therapeutic options in anaesthesia and intensive care medicine. It may have particular roles in pain management, modulation of haemodynamics and treatment of shock.


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C. Kakazu, M. Lippmann, R. A. White, A. T. P. Skrabanja, E. A. C. Bouman, and P. C. Dagnelie
Additional use for adenosine in anaesthesia and surgery
Br. J. Anaesth., December 1, 2005; 95(6): 836 - 837.
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