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BJA Advance Access originally published online on February 4, 2005
British Journal of Anaesthesia 2005 94(4):524-529; doi:10.1093/bja/aei079
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2005. All rights reserved. For Permissions, please e-mail: journal.permissions{at}oupjournals.org

Long-term evaluation of motor function following intraneural injection of ropivacaine using walking track analysis in rats

G. Iohom1, G. B. Lan2, D. P. Diarra1, Y. Grignon3, B. P. Kinirons4, F. Girard5, M. Merle2, G. Granier3, V. Cahn3 and H. Bouaziz1,*

1 Department of Anesthesiology and Intensive Care, Hôpital Central, 54035 Nancy cedex, France. 2 Surgical Research Institute (IRC), CHU Nancy, France. 3 Department of Anatomo-pathology, Hôpital Central, 54035 Nancy cedex, France. 4 Anesthetic Department, University College Hospital, Galway, Ireland. 5 Service d'Epidémiologie et Evaluation Cliniques, Hôpital Marin, 54035 Nancy cedex, France

* Corresponding author. E-mail: h.bouaziz{at}chu-nancy.fr

Background. There is a paucity of data regarding neurologic function following nerve injury. Our objective was the long-term evaluation of motor function following intraneural injection of ropivacaine in rats using the sciatic function index (SFI), derived from walking track analysis.

Methods. Rats were randomly assigned to one of four groups of 13 animals each. A needle was inserted under magnification into the left sciatic nerve and 0.2 ml of normal saline, formalin 15%, ropivacaine 0.2 or 0.75% were injected intraneurally. The right side was sham operated. Walking track analysis was performed the day before and on days 1, 4, 7, 11, 15, 18, 21, and 67 following intraneural injection. At the end of the experiment (day 67) a semi-quantitative evaluation of neuropathologic changes was performed by three independent observers.

Results. Animals treated with saline and ropivacaine (0.2 and 0.75%) had no detectable impairment of motor function at any time point. In contrast, rats treated with formalin had a complete loss of motor function immediately after the intraneural injection, which persisted until day 21 and returned to normal by day 67. Important histopathologic changes (score=2) with excellent inter-observer agreement were seen only in the group treated with formalin. This applied to both axonal degeneration and Schwann cell density evaluations.

Conclusions. These findings suggest that intraneural injections of ropivacaine at concentrations routinely used in clinical practice appear to have no deleterious effect on sciatic nerve motor function in this experimental rat model.


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