Skip Navigation


BJA Advance Access originally published online on September 3, 2004
British Journal of Anaesthesia 2004 93(5):634-638; doi:10.1093/bja/aeh252
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
93/5/634    most recent
aeh252v2
aeh252v1
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Oh, Y. J.
Right arrow Articles by Kwak, Y. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oh, Y. J.
Right arrow Articles by Kwak, Y. L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© The Board of Management and Trustees of the British Journal of Anaesthesia 2004

Effects of milrinone on jugular bulb oxygen saturation and cerebrovascular carbon dioxide reactivity in patients undergoing coronary artery bypass graft surgery

Y. J. Oh1, S. H. Kim2, H. K. Shinn3, C. S. Lee3, Y. W. Hong1,4 and Y. L. Kwak1,4,*

1 Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, and 4 Yonsei Cardiovascular Research Institute, Yonsei University School of Medicine, Seoul, Korea. 2 Department of Anesthesiology and Pain Medicine, Yonsei University School of Medicine, Seoul, Korea. 3 Department of Anesthesiology and Pain Medicine, Inha University School of Medicine, Inchon, Korea

* Corresponding author. E-mail: yjoh{at}yumc.yonsei.ac.kr

Background. Jugular bulb oxygen saturation () is a surrogate marker for global cerebral oxygenation. The effect of milrinone on and the cerebrovascular carbon dioxide reactivity (CCO2R) was investigated.

Methods. Thirty patients scheduled for coronary artery bypass graft surgery (CABG) were studied prospectively. After sternotomy, normoventilation (at T1; =4.7–5.0 kPa) and hyperventilation (at T2; =3.3–3.7 kPa) were induced and the changes in () and (), and (CCO2R) were measured. After normoventilation was re-established (at T3), milrinone 50 µg kg–1 was given (at T4), followed by hyperventilation (at T5), and , and CCO2R were measured.

Results. After milrinone administration at normoventilation (T3 and T4), cardiac index and mixed venous oxygen saturation increased, while mean arterial pressure and systemic vascular resistance index decreased, without a significant change in . Before milrinone administration (T1 and T2), hyperventilation decreased and , and showed positive linear correlation with . After milrinone administration (T4 and T5), hyperventilation decreased and , and showed positive linear correlation with . There was no significant difference in CCO2R before and after milrinone administration (13.3 (5.7)% kPa–1 and 12.3 (3.9)% kPa–1, respectively).

Conclusions. Although milrinone induced significant haemodynamic changes, and CCO2R were unchanged during its administration.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.