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BJA Advance Access originally published online on June 25, 2004
British Journal of Anaesthesia 2004 93(2):275-287; doi:10.1093/bja/aeh174
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© The Board of Management and Trustees of the British Journal of Anaesthesia 2004

Updates in perioperative coagulation: physiology and management of thromboembolism and haemorrhage

T. Bombeli1 and D. R. Spahn2,*

1 Coagulation Laboratory, Division of Haematology, University Hospital of Zürich, Sternwartstrasse 14, CH-8091 Zürich, Switzerland. 2 Department of Anaesthesiology, University Hospital of Lausanne, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland

* Corresponding author. E-mail: donat.spahn{at}chuv.hospvd.ch

Understanding of blood coagulation has evolved significantly in recent years. Both new coagulation proteins and inhibitors have been found and new interactions among previously known components of the coagulation system have been discovered. This increased knowledge has led to the development of various new diagnostic coagulation tests and promising antithrombotic and haemostatic drugs. Several such agents are currently being introduced into clinical medicine for both the treatment or prophylaxis of thromboembolic disease and for the treatment of bleeding. This review aims to elucidate these new concepts and to outline some consequences for clinical anaesthesia and perioperative medicine.


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