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BJA Advance Access originally published online on April 2, 2004
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British Journal of Anaesthesia, 2004, Vol. 92, No. 5 658-661
© 2004 The Board of Management and Trustees of the British Journal of Anaesthesia

Clinical Investigations

Is prolongation of the QTc interval during isoflurane anaesthesia more prominent in women pretreated with anthracyclines for breast cancer?{dagger}

R. Owczuk*,1, M. A. Wujtewicz1, W. Sawicka1, M. Wujtewicz1 and M. Swierblewski2

1 Department of Anaesthesiology and Intensive Therapy and 2 Department of Oncological Surgery, Medical University of Gdansk, Debinki str. 7, 80-211 Gdansk, Poland

*Corresponding author. E-mail: r.owczuk{at}wp.pl
{dagger}This study was presented in part at the Euroanaesthesia 2003 Meeting, Glasgow, UK, May 31 to June 3, 2003 [Eur J Anaesth 2003; 20 (Suppl. 30): 126; Abstract 480].

Background. Inhalation anaesthetics and anthracycline chemotherapeutic drugs may both prolong the QT interval of the electrocardiogram. We investigated whether isoflurane may induce or augment QTc prolongation in patients who had previously received cancer chemotherapy including anthracycline drugs.

Methods. Forty women undergoing surgery for breast cancer were included in the study. They were divided into two groups: (A) women previously treated with anthracyclines (n=20); and (B) women not treated with antineoplastic drugs (n=20). All patients received a standardized balanced anaesthetic in which isoflurane 0.5 vol% was used. The QT and corrected QT intervals were measured before anaesthesia, after induction and tracheal intubation, after 1, 5, 15, 30, 60 and 90 min of anaesthesia, and during recovery.

Results. In both groups we observed a tendency to QTc prolongation, but statistically significant differences among baseline values and values observed during isoflurane-containing anaesthesia were seen only in group A. During anaesthesia, significant differences in QTc values between the two groups were observed.

Conclusion. In female patients pretreated with anthracyclines for breast cancer, the tendency to QTc prolongation during isoflurane-containing general anaesthesia was more strongly expressed than in patients without previous chemotherapy.

Br J Anaesth 2004; 92: 658–61


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