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British Journal of Anaesthesia, 2003, Vol. 91, No. 4 592-594
© 2003 The Board of Management and Trustees of the British Journal of Anaesthesia

Short Communications

Release by hypoxia of a soluble vasoconstrictor from rabbit small pulmonary arteries

N. P. Talbot, P. A. Robbins and K. L. Dorrington*

University Laboratory of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK

Corresponding author. E-mail: keith.dorrington@physiol.ox.ac.uk

Background. Soluble pulmonary vasoconstrictors released in response to hypoxia have been reported in pig and rat preparations, but not in rabbit preparations.

Methods. We used myography to evaluate the contribution of a soluble factor to constriction in rabbit small pulmonary arteries (external diameter 300–475 µm) exposed to 45 min hypoxia (PO2=9 mm Hg).

Results. Hypoxia produced gradually intensifying constriction. Return to euoxia (PO2=145 mm Hg) for 30 min relaxed only approximately 30% of the constriction, whereas elution of the myograph bath yielded full relaxation. Reapplication of the eluent gradually restored the constriction to its pre-elution level over a 30-min period.

Conclusions. In this closed system, a soluble factor contributes substantially to hypoxic pulmonary vasoconstriction.

Br J Anaesth 2003; 91: 592–4


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