British Journal of Anaesthesia, 2003, Vol. 91, No. 4 551-565
© 2003 The Board of Management and Trustees of the British Journal of Anaesthesia
Review Article |
Anaesthetics and cardiac preconditioning. Part I. Signalling and cytoprotective mechanisms
1 Institute of Anaesthesiology, University Hospital Zurich, Zurich, Switzerland. 2 Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
Corresponding author: E-mail: michael.zaugg@usz.ch
Abstract
Cardiac preconditioning represents the most potent and consistently reproducible method of rescuing heart tissue from undergoing irreversible ischaemic damage. Major milestones regarding the elucidation of this phenomenon have been passed in the last two decades. The signalling and amplification cascades from the preconditioning stimulus, be it ischaemic or pharmacological, to the putative end-effectors, including the mechanisms involved in cellular protection, are discussed in this review. Volatile anaesthetics and opioids effectively elicit pharmacological preconditioning. Anaesthetic-induced preconditioning and ischaemic preconditioning share many fundamental steps, including activation of G-protein-coupled receptors, multiple protein kinases and ATP-sensitive potassium channels (KATP channels). Volatile anaesthetics prime the activation of the sarcolemmal and mitochondrial KATP channels, the putative end-effectors of preconditioning, by stimulation of adenosine receptors and subsequent activation of protein kinase C (PKC) and by increased formation of nitric oxide and free oxygen radicals. In the case of desflurane, stimulation of 
- and ß-adrenergic receptors may also be of importance. Similarly, opioids activate 
- and 
-opioid receptors, and this also leads to PKC activation. Activated PKC acts as an amplifier of the preconditioning stimulus and stabilizes, by phosphorylation, the open state of the mitochondrial KATP channel (the main end-effector in anaesthetic preconditioning) and the sarcolemmal KATP channel. The opening of KATP channels ultimately elicits cytoprotection by decreasing cytosolic and mitochondrial Ca2+ overload.
Br J Anaesth 2003; 91: 551–65
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