Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (10)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Galley, H. F.
Right arrow Articles by Webster, N. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Galley, H. F.
Right arrow Articles by Webster, N. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 2003, Vol. 91, No. 3 424-426
© 2003 The Board of Management and Trustees of the British Journal of Anaesthesia

Short Communications

Genotype and interleukin-10 responses after cardiopulmonary bypass{dagger}

H. F. Galley*, P. R. Lowe, R. L. Carmichael and N. R. Webster

Academic Unit of Anaesthesia and Intensive Care, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK

Corresponding author. E-mail: h.f.galley@abdn.ac.uk
{dagger}Presented in part to the Anaesthetic Research Society, Sheffield, UK, April 2002.

Background. The pro- and anti-inflammatory cytokine balance has been implicated in outcome from inflammatory conditions, and cardiopulmonary bypass is associated with a marked inflammatory response. Interleukin-10 (IL-10) is an anti-inflammatory cytokine and levels have been shown to be highest in those patients who develop sepsis after trauma or surgery. IL-10 levels vary between individuals and genotype may dictate the IL-10 response. We therefore investigated IL-10 genotype, circulating IL-10 concentrations and outcome in terms of organ dysfunction 24 h after cardiopulmonary bypass.

Methods. Blood samples were obtained from 150 patients before, and 3, and 24 h after cardiopulmonary bypass. IL-10 was measured by enzyme immunoassay. The single nucleotide polymorphism at –1082 base pairs was detected by restriction fragment length polymorphism analysis. Post-bypass organ system dysfunction was defined prospectively.

Results. IL-10 concentrations were increased 3 h after bypass (P<0.0001) and were still increased at 24 h (P<0.0001). Homozygosity for the G allele was associated with lower median (range) maximal IL-10 levels at 3 h (44 (13–136) pg ml–1) compared with the A allele (118 (39–472) pg ml–1; P=0.042). Those patients who developed at least one organ dysfunction (n=33) had higher IL-10 levels 3 h after surgery (242 (18–694) pg ml–1) compared with those without organ dysfunction (77 (7–586) pg ml–1; P=0.001, n=117).

Conclusions. The G allele of the –1082 base pair single nucleotide polymorphism in the IL-10 gene is associated with lower IL-10 release after cardiopulmonary bypass. High levels of IL-10 secretion are associated with organ dysfunction 24 h after surgery.

Br J Anaesth 2003; 91: 424–6


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
R. B. Yates and M. Stafford-Smith
The genetic determinants of renal impairment following cardiac surgery.
Seminars in Cardiothoracic and Vascular Anesthesia, December 1, 2006; 10(4): 314 - 326.
[Abstract] [PDF]

Home page
 Anesth. Analg.Home page
M. Sander, C. von Heymann, V. v. Dossow, C. Spaethe, W. F. Konertz, U. Jain, and C. D. Spies
Increased interleukin-6 after cardiac surgery predicts infection.
Anesth. Analg., June 1, 2006; 102(6): 1623 - 1629.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. N. Gong, B. T. Thompson, P. L. Williams, W. Zhou, M. Z. Wang, L. Pothier, and D. C. Christiani
Interleukin-10 polymorphism in position -1082 and acute respiratory distress syndrome.
Eur. Respir. J., April 1, 2006; 27(4): 674 - 681.
[Abstract] [Full Text] [PDF]

Home page
 J Intensive Care MedHome page
R. S. Jawa, M. N. Kulaylat, H. Baumann, and M. T. Dayton
What Is New in Cytokine Research Related to Trauma/Critical Care
J Intensive Care Med, March 1, 2006; 21(2): 63 - 85.
[Abstract] [PDF]

Home page
 J Am Coll CardiolHome page
M. V. Podgoreanu and D. A. Schwinn
New Paradigms in Cardiovascular Medicine: Emerging Technologies and Practices: Perioperative Genomics
J. Am. Coll. Cardiol., December 6, 2005; 46(11): 1965 - 1977.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.