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British Journal of Anaesthesia, 2003, Vol. 90, No. 4 434-439
© 2003 The Board of Management and Trustees of the British Journal of Anaesthesia

Clinical Investigations

Clonidine premedication improves metabolic control in type 2 diabetic patients during ophthalmic surgery{dagger}

M. Belhoula, J. P. Ciébiéra, A. De La Chapelle, N. Boisseau, D. Coeurveille and M. Raucoules-Aimé

Department of Anaesthesia, Hôpital l‘Archet, 151 Route de Saint Antoine de Ginestière BP, F-3079-06202 Nice, Cedex 3, France

Corresponding author. E-mail: anesthesiologie@chu-nice.fr
{dagger}This article is accompanied by Editorial II.

Background. In stressful conditions, increasing blood glucose concentrations are closely related to an increase in catecholamines and cortisol release. Clonidine, a centrally acting {alpha}2-adrenoceptor agonist, has neuroendocrine effects, including inhibition of sympathoadrenal activity. We therefore evaluated the effect of clonidine on blood glucose control and insulin requirements during ophthalmic surgery when given as premedication in type 2 diabetic patients.

Methods. After randomization, patients were premedicated with clonidine or flunitrazepam (control). Patients were given insulin by continuous i.v. infusion to maintain blood glucose in the range 5.5–11.1 mmol litre–1. Blood glucose concentrations were measured every 15 min during surgery, and hourly for 6 h after surgery. Plasma C-peptide and counter-regulatory hormones were also measured.

Results. Glycaemia was significantly lower in the clonidine group (P<0.01) and the median amount of insulin administered was significantly reduced: clonidine group 9.0 (interquartile range 5.1) units; control 18.6 (10.2) units; P<0.01). Plasma catecholamine concentrations were lower in patients given clonidine (P<0.05) but there was no difference in cortisol concentrations.

Conclusion. Premedication of type 2 diabetic patients with clonidine 90 min before surgery improves blood glucose control and decreases insulin requirements during ophthalmic surgery.

Br J Anaesth 2003; 90: 434–9


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