British Journal of Anaesthesia, 2003, Vol. 90, No. 2 166-172
© 2003 The Board of Management and Trustees of the British Journal of Anaesthesia
Clinical Investigations |
Parecoxib sodium has opioid-sparing effects in patients undergoing total knee arthroplasty under spinal anaesthesia
1 Pharmacia, 5200 Old Orchard Road, Skokie, IL 60077, USA. 2 Hessing’sche Orthopedic Clinic, Hessingstr, Augsburg, Germany
Corresponding author. E-mail: richard.c.hubbard@pharmacia.com 
Declaration of interest. The study was sponsored by Pharmacia Corporation and parecoxib sodium was provided by Pharmacia Corporation.
Background. This multicentre, double-blind, placebo-controlled study compared the opioid-sparing effectiveness and clinical safety of parecoxib sodium over 48 h, in 195 postoperative patients after routine total knee replacement surgery.
Methods. Elective total primary knee arthroplasty was performed under spinal anaesthesia, with a single dose of spinal bupivacaine 10–20 mg, and intraoperative sedation with midazolam 0.5–1.0 mg i.v., or propofol <6 mg kg–1 h–1. Patients were randomized to receive either parecoxib sodium 20 mg twice daily (bd) i.v. (n=65), parecoxib sodium 40 mg bd i.v. (n=67), or placebo (n=63) at the completion of surgery, and after 12, 24, and 36 h. Morphine (1–2 mg) was taken by patient-controlled analgesia or by bolus doses after 30 min.
Results. Patients receiving parecoxib sodium 20 mg bd and 40 mg bd consumed 15.6% and 27.8% less morphine at 24 h than patients taking placebo (both P<0.05). Both doses of parecoxib sodium administered with morphine provided significantly greater pain relief than morphine alone from 6 h (P<0.05). A global evaluation of study medication demonstrated a greater level of satisfaction among patients taking parecoxib sodium than those taking placebo. Parecoxib sodium administered in combination with morphine was well tolerated. However, a reduction in opioid-type side-effects was not demonstrated in the parecoxib sodium groups.
Conclusion. Parecoxib sodium provides opioid-sparing analgesic effects in postoperative patients.
Br J Anaesth 2003; 90: 166–72
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. A. Schug, G. P. Joshi, F. Camu, S. Pan, and R. Cheung Cardiovascular Safety of the Cyclooxygenase-2 Selective Inhibitors Parecoxib and Valdecoxib in the Postoperative Setting: An Analysis of Integrated Data Anesth. Analg., January 1, 2009; 108(1): 299 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. Viscusi, J. S. Gimbel, A. M. Halder, M. Snabes, M. T. Brown, and K. M. Verburg A Multiple-Day Regimen of Parecoxib Sodium 20 mg Twice Daily Provides Pain Relief After Total Hip Arthroplasty Anesth. Analg., August 1, 2008; 107(2): 652 - 660. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zhang, E. L. Ding, and Y. Song Adverse Effects of Cyclooxygenase 2 Inhibitors on Renal and Arrhythmia Events: Meta-analysis of Randomized Trials JAMA, October 4, 2006; 296(13): 1619 - 1632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Munsterhjelm, T. T. Niemi, O. Ylikorkala, P. J. Neuvonen, and P. H. Rosenberg Influence on platelet aggregation of i.v. parecoxib and acetaminophen in healthy volunteers Br. J. Anaesth., August 1, 2006; 97(2): 226 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. P. Malan Jr, S. Gordon, R. Hubbard, and M. Snabes The Cyclooxygenase-2-Specific Inhibitor Parecoxib Sodium Is as Effective as 12 mg of Morphine Administered Intramuscularly for Treating Pain After Gynecologic Laparotomy Surgery Anesth. Analg., February 1, 2005; 100(2): 454 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Apfelbaum, T. J. Gan, S. Zhao, D. B. Hanna, and C. Chen Reliability and Validity of the Perioperative Opioid-Related Symptom Distress Scale Anesth. Analg., September 1, 2004; 99(3): 699 - 709. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kranke, A. M. Morin, N. Roewer, and L. H. Eberhart Patients' Global Evaluation of Analgesia and Safety of Injected Parecoxib for Postoperative Pain: A Quantitative Systematic Review Anesth. Analg., September 1, 2004; 99(3): 797 - 806. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. F. Ekman and L. A. Koman Acute Pain Following Musculoskeletal Injuries and Orthopaedic Surgery. Mechanisms and Management J. Bone Joint Surg. Am., June 1, 2004; 86(6): 1316 - 1327. [Full Text] [PDF]
|
|
|
|
|
|
T. J. Gan, G. P. Joshi, E. Viscusi, R. Y. Cheung, W. Dodge, J. G. Fort, and C. Chen Preoperative Parenteral Parecoxib and Follow-Up Oral Valdecoxib Reduce Length of Stay and Improve Quality of Patient Recovery After Laparoscopic Cholecystectomy Surgery Anesth. Analg., June 1, 2004; 98(6): 1665 - 1673. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. C. Walker and D. S. Wagner Treatment of Pain in Pediatric Patients Journal of Pharmacy Practice, August 1, 2003; 16(4): 261 - 275. [Abstract] [PDF]
|
|