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British Journal of Anaesthesia, 2002, Vol. 89, No. 5 764-766
© 2002 The Board of Management and Trustees of the British Journal of Anaesthesia

Short Communications

Sevoflurane and propofol decrease intraocular pressure equally during non-ophthalmic surgery and recovery

S. Sator-Katzenschlager*,1,2, E. Deusch2, S. Dolezal1, A. Michalek-Sauberer1,2, R. Grubmüller1, G. Heinze3 and A. Wedrich4

1 Department of Anaesthesiology and General Intensive Care A, University of Vienna, Austria. 2 Department of Anaesthesiology and General Intensive Care B, University of Vienna, Austria. 3 Department of Medical Computer Science, University of Vienna, Austria. 4 Department of Ophthalmology and Optometrics, University of Vienna, Austria*Corresponding author: Department of Anaesthesiology and General Intensive Care, University of Vienna, Währinger Gürtel 1820, A-1090 Vienna, Austria

Background. To provide good control of intraocular pressure (IOP) during anaesthesia and surgery, we conducted a study comparing the effects on IOP during maintenance and recovery of sevoflurane vs propofol anaesthesia in 33 patients (ASA I–II) undergoing elective non- ophthalmic surgery.

Methods. Anaesthesia was induced with propofol 2 mg kg–1, fentanyl 2 µg kg–1 and vecuronium 0.1 mg kg–1. Patients were allocated randomly to receive either propofol 4–8 mg kg–1 h–1 (group P; n=16) or 1.5–2.5 vol% sevoflurane (group S; n=17) for maintenance of anaesthesia. Fentanyl 2–4 µg kg–1 was added if necessary. The lungs were ventilated with 50% air in oxygen. Blood pressure, heart rate, oxygen saturation and end-tidal carbon dioxide were measured before and throughout anaesthesia and in the recovery room. IOP was determined with applanation tonometry (Perkins) by one ophthalmologist blinded to the anaesthetic technique.

Results. There was a significant decrease in IOP after induction and during maintenance of anaesthesia in both groups. No significant differences in IOP between the two groups was found.

Conclusion. Sevoflurane maintains the IOP at an equally reduced level compared with propofol.

Br J Anaesth 2002; 89: 764–6


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