Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Lejus, C.
Right arrow Articles by Pinaud, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lejus, C.
Right arrow Articles by Pinaud, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 2002, Vol. 89, No. 5 693-696
© 2002 The Board of Management and Trustees of the British Journal of Anaesthesia

Clinical Investigations

Fluoride excretion in children after sevoflurane anaesthesia

C. Lejus*,1, C. Le Roux1, E. Legendre1, M. Renaudin1, H. L. Boiteau2 and M. Pinaud1

1 Department of Anaesthesiology, Hôtel Dieu, C.H.U. Nantes, France. 2 Société d’Etude des Risques Toxiques, Nantes, France*Corresponding author: Service d’Anesthésie et de Réanimation Chirurgicale, Hôtel - Dieu, F-44093 Nantes Cedex 01, France

Background. Defluorination of sevoflurane is catalysed by the hepatic enzyme cytochrome P450 2E1 (CYP2E1). Data about the ontogenesis (developmental variations in activity) of this enzyme suggest a low metabolism of sevoflurane during the first months of life.

Methods. To test this hypothesis, 45 children less than 48 months of age undergoing sevoflurane anaesthesia were enrolled in a prospective open clinical trial. The 24 h urine fluoride excretion was measured in five groups of children (A, <4 months; B, 4 to <8 months; C, 8–12 months; D, >12–24 months; and E, >24–48 months old). An index of sevoflurane metabolism (ISM) was calculated as the ratio of fluoride excretion, cumulative expiratory sevoflurane concentrations measured every minute during anaesthesia, and body surface area. ISM values were median (IQ 25–75%).

Results. ISM was lower in group A (n=9, 18.9 (11.2–29.5) than group C (n=11, 44.2 (37.5–53.5), P<0.05), group D (n=7, 52.6 (45.8–68.4), P<0.01) and group E (n=9, 53.6 (50.7–85), P<0.001). Median ISM expressed as a function of median age, exponentially increased with a rapid increase during the first months of life, followed by a slower increase after 10 months of age.

Conclusion. These results suggest that, in children less than 48 months, sevoflurane metabolism parallels postnatal development of CYP2E1.

Br J Anaesth 2002; 89: 693–6


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.