Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (20)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Telci, L.
Right arrow Articles by Akpir, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Telci, L.
Right arrow Articles by Akpir, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 2002, Vol. 89, No. 4 594-598
© 2002 The Board of Management and Trustees of the British Journal of Anaesthesia

Clinical Investigations

Evaluation of effects of magnesium sulphate in reducing intraoperative anaesthetic requirements

L. Telci1, F. Esen*,1, D. Akcora1, T. Erden1, A. T. Canbolat2 and K. Akpir1

1 Department of Anaesthesiology and Intensive Care, Faculty of Medicine, University of Istanbul, Istanbul, Turkey. 2 Department of Neurosurgery, Faculty of Medicine, University of Istanbul Istanbul, Turkey*Corresponding author: Department of Anaesthesiology and Intensive Care, Faculty of Medicine, University of Istanbul, 34390 Capa Istanbul, Turkey

Background. The present randomized, placebo-controlled, double-blind study was designed to assess the effect of peroperatively administered i.v. magnesium sulphate on anaesthetic and analgesic requirements during total i.v. anaesthesia.

Methods. Eighty-one patients (36 women, 45 men) undergoing elective spinal surgery were included in one of two parallel groups. The magnesium group received magnesium sulphate 30 mg kg–1 as a bolus before induction of anaesthesia and 10 mg kg–1 h–1 by continuous i.v. infusion during the operation period. The same volume of isotonic solution was administered to the control group. Anaesthesia was maintained with propofol (administered according to the bispectral index) and remifentanil (adjusted according to heart rate and arterial blood pressure) infusions.

Results. A significant reduction in hourly propofol consumption was observed with magnesium administration. For example, the mean infusion rate of propofol in the second hour of the operation was 7.09 mg kg–1 h–1 in the control group vs 4.35 mg kg–1 h–1 in the magnesium group (P<0.001). The magnesium group required significantly less remifentanil (P<0.001) and vecuronium (P<0.001). No side-effects were observed with magnesium administration.

Conclusion. The administration of magnesium led to a significant reduction in the requirements for anaesthetic drugs during total i.v. anaesthesia with propofol, remifentanil and vecuronium.

Br J Anaesth 2002; 89: 594–8


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
J.-H. Ryu, M.-H. Kang, K.-S. Park, and S.-H. Do
Effects of magnesium sulphate on intraoperative anaesthetic requirements and postoperative analgesia in gynaecology patients receiving total intravenous anaesthesia
Br. J. Anaesth., March 1, 2008; 100(3): 397 - 403.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
T. O. Seyhan, M. Tugrul, M. O. Sungur, S. Kayacan, L. Telci, K. Pembeci, and K. Akpir
Effects of three different dose regimens of magnesium on propofol requirements, haemodynamic variables and postoperative pain relief in gynaecological surgery
Br. J. Anaesth., February 1, 2006; 96(2): 247 - 252.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
C. J. L. McCartney, A. Sinha, and J. Katz
A Qualitative Systematic Review of the Role of N-Methyl-D-Aspartate Receptor Antagonists in Preventive Analgesia
Anesth. Analg., May 1, 2004; 98(5): 1385 - 1400.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.