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British Journal of Anaesthesia, 2002, Vol. 89, No. 3 376-381
© 2002 The Board of Management and Trustees of the British Journal of Anaesthesia

Clinical Investigations

Impaired explicit memory after recovery from propofol/sufentanil anaesthesia is related to changes in the midlatency auditory evoked response

I. Rundshagen*,1, K. Schnabel2 and J. Schulte am Esch3

1 Department of Anaesthesiology, University Hospital Charité, Campus Charité Mitte, Schumannstrasse 20/21, D-10117 Berlin, Germany. 2 Department of Psychology, University of Michigan, Ann Arbor, USA. 3 Department of Anaesthesiology, University Hospital Eppendorf, Hamburg, Germany *Corresponding author

Background. Midlatency auditory evoked responses (MLAER) can distinguish different stages of anaesthesia. We studied MLAER during emergence from propofol/sufentanil anaesthesia in relation to recovery of explicit memory.

Methods. MLAER were recorded in 29 healthy patients before and during anaesthesia and during emergence until the patients opened their eyes spontaneously. After a structured interview the next day, patients were classified into those with and without explicit memory of the recovery period. Latencies Na, Pa and Nb and the peak-to-peak amplitudes NaPa and PaNb were compared between the groups by multivariate analysis of variance. Results are mean (SD).

Results. At eye opening (37 (12) min after the end of anaesthesia) the latency Nb (47 (5) compared with 41 (5) ms; P<0.001) was prolonged and the amplitude PaNb (1.3 (0.8) compared with 1 (0.5) ms; P=0.012) was greater than the baseline value, respectively. The Nb latency was significantly shorter in patients with explicit memory (49 (2) ms compared with 45 (1); P=0.041).

Conclusions. Large intra- and inter-individual variability in the MLAER values limited their ability to predict memory responses in individual patients during emergence from propofol/sufentanil anaesthesia.

Br J Anaesth 2002; 89: 376–81


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