British Journal of Anaesthesia, 2002, Vol. 88, No. 6 785-789
© 2002 The Board of Management and Trustees of the British Journal of Anaesthesia
Clinical Investigations |
Comparison of the effects of sevoflurane and propofol on cortical somatosensory evoked potentials
1Department of Anaesthesiology, 2Department of Neurophysiology, 3Department of Clinical Statistics, Nice School of Medicine, University of Nice-Sophia-Antipolis, Hôpital Archet II, 151 route Saint-Antoine de Ginestière, BP 3079, F-06202 Nice Cedex 3, CHU de Nice, France*Corresponding author: 156 Bd de la madeleine, F-06000 Nice, France
Background. Propofol (P) and sevoflurane (S) are potential anaesthetic agents if electrophysiological monitoring is required during spinal surgery. They allow rapid recovery and do not depress cortical somatosensory evoked potentials (SSEP) as much as other agents. The effects of these agents on SSEP have not been compared before.
Methods. Twenty-four patients were allocated randomly to receive either S (n=12) or P (n=12). SSEP evoked by electrical stimulation of the posterior tibial nerve at the ankle were recorded before anaesthesia. The cortical potential P40 was recorded (latency P40 and amplitudes N29P40 and P40N50). The anaesthetic concentration was adjusted gradually to obtain three predetermined ranges of values of bispectral index (BIS): 45–55, 35–45 and 25–35. For each range, a stable state was maintained for 10 min and SSEP were recorded.
Results. For the BIS 45–55 range, compared with preoperative values, P40 latency increased during S [mean change +2 (SD 0.6) ms] but not during P [+0.4 (0.2) ms (P= 0.12)] and both amplitudes (N29P40 and P40N50) decreased with S. Increasing S concentration caused a dose-dependent depression of SSEP. P did not have a statistically significant effect on the recordings and the signals remained stable in each BIS range.
Conclusion. Sevoflurane affected SSEP recordings in a dose-dependent fashion. Propofol had a minimal effect on SSEP recordings.
Br J Anaesth 2002; 88: 785–9
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Westeren-Punnonen, H. Ypparila-Wolters, J. Partanen, K. Nieminen, A. Hyvarinen, and H. Kokki Somatosensory Evoked Potentials by Median Nerve Stimulation in Children During Thiopental/Sevoflurane Anesthesia and the Additive Effects of Ketoprofen and Fentanyl Anesth. Analg., September 1, 2008; 107(3): 799 - 805. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Soundararajan and M. Cunliffe Anaesthesia for spinal surgery in children Br. J. Anaesth., July 1, 2007; 99(1): 86 - 94. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hermanns, P. Lipfert, S. Meier, M. Jetzek-Zader, R. Krauspe, and M. F. Stevens Cortical somatosensory-evoked potentials during spine surgery in patients with neuromuscular and idiopathic scoliosis under propofol-remifentanil anaesthesia Br. J. Anaesth., March 1, 2007; 98(3): 362 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Conti, D. G. Iacopino, V. Fodale, S. Micalizzi, O. Penna, and L. B. Santamaria Cerebral haemodynamic changes during propofol-remifentanil or sevoflurane anaesthesia: transcranial Doppler study under bispectral index monitoring Br. J. Anaesth., September 1, 2006; 97(3): 333 - 339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Schwilden, E. Kochs, M. Daunderer, Ch. Jeleazcov, B. Scheller, G. Schneider, J. Schuttler, D. Schwender, G. Stockmanns, and E. Poppel Concurrent recording of AEP, SSEP and EEG parameters during anaesthesia: a factor analysis Br. J. Anaesth., August 1, 2005; 95(2): 197 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Fletcher, A. R. Hinn, C. M. Heard, L. S. Georges, E. B. Freid, A. Keifer, S. D. Brooks, A. G. Bailey, and R. D. Valley The Effects of Isoflurane and Desflurane Titrated to a Bispectral Index of 60 on the Cortical Somatosensory Evoked Potential During Pediatric Scoliosis Surgery Anesth. Analg., June 1, 2005; 100(6): 1797 - 1803. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. C. Liu, H. K. Wong, C. P. Chia, H. J. Lim, Z. Y. Chen, and T. L. Lee Effects of isoflurane and propofol on cortical somatosensory evoked potentials during comparable depth of anaesthesia as guided by bispectral index Br. J. Anaesth., February 1, 2005; 94(2): 193 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Clapcich, R. G. Emerson, D. P. Roye Jr., H. Xie, E. J. Gallo, K. C. Dowling, B. Ramnath, and E. J. Heyer The Effects of Propofol, Small-Dose Isoflurane, and Nitrous Oxide on Cortical Somatosensory Evoked Potential and Bispectral Index Monitoring in Adolescents Undergoing Spinal Fusion Anesth. Analg., November 1, 2004; 99(5): 1334 - 1340. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Stecker Evoked Potentials during Cardiac and Major Vascular Operations Seminars in Cardiothoracic and Vascular Anesthesia, June 1, 2004; 8(2): 101 - 111. [Abstract] [PDF]
|
|
|
|
|
|
W. Meissner, T. Weiss, R. H. Trippe, H. Hecht, C. Krapp, and W. H. Miltner Acupuncture Decreases Somatosensory Evoked Potential Amplitudes to Noxious Stimuli in Anesthetized Volunteers Anesth. Analg., January 1, 2004; 98(1): 141 - 147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. G. Logginidou, B.-H. Li, D.-P. Li, J. S. Lohmann, H. G. Schuler, N. A. DiVittore, S. Kreiser, and A. J. Cronin Propofol Suppresses the Cortical Somatosensory Evoked Potential in Rats Anesth. Analg., December 1, 2003; 97(6): 1784 - 1788. [Abstract] [Full Text] [PDF]
|
|