Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (22)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Preckel, B.
Right arrow Articles by Rütten, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Preckel, B.
Right arrow Articles by Rütten, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 2002, Vol. 88, No. 2 264-269
© 2002 The Board of Management and Trustees of the British Journal of Anaesthesia

Laboratory Investigations

Xenon produces minimal haemodynamic effects in rabbits with chronically compromised left ventricular function

B. Preckel*,1, W. Schlack1, T. Heibel2 and H. Rütten2

1Klinik für Anaesthesiologie, Universitätsklinikum Düsseldorf, Postfach 10 10 07, D-40001 Dusseldorf and 2Aventis Pharma Deutschland GmbH, Frankfurt, Germany*Corresponding author

Background. Xenon has only minimal haemodynamic side-effects on normal myocardium and might be a preferable anaesthetic agent for patients with heart failure. We studied the haemodynamic changes caused by 70% xenon in rabbits with chronically compromised left ventricular (LV) function.

Methods. Anaesthetized rabbits were thoracotomized and a major coronary artery was ligated to induce ischaemic heart disease. Nine weeks later, rabbits were again anaesthetized (ketamine/propofol), and haemodynamics were measured during inhalation of 70% xenon using echocardiography [LV end-diastolic dimension (LVedD), fractional shortening (FS), velocity of circumferential fibre shortening (VcF), ejection fraction (EF)] in closed-chest animals. Subsequently, rabbits were thoracotomized and instrumented for measurement of LV pressure (tip manometer), LV dP/dtmax and cardiac output (ultrasonic flow probe). Haemodynamics were recorded again during inhalation of 70% xenon.

Results. All rabbits had compromised LV function 9 weeks after coronary artery ligation. Mean LVedD increased from 12.9 (SD 0.9) mm to 17.1 (0.4) mm; EF decreased from 73 (9) to 64 (8)%; FS decreased from 36 (7) to 29 (5)%; VcF decreased from 28.9 (6.8) to 17.6 (4.7) mm s–1; all P<0.05. Inhalation of 70% xenon had no effect on haemodynamics in closed-chest rabbits, as measured by echocardiography. After invasive instrumentation, small decreases in LV pressure from 78 (20) to 72 (19) mm Hg, LV dP/dtmax from 3081 (592) to 2633 (503) mm Hg s–1 and cardiac output from 239 (69) to 225 (71) ml min–1 were observed during xenon inhalation (all P<0.05).

Conclusion. These data show that xenon has only minimal negative inotropic effects in rabbits with LV dysfunction after coronary artery ligation.

Br J Anaesth 2002; 88: 264–9


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
Y. Mio, Y. H. Shim, E. Richards, Z. J. Bosnjak, P. S. Pagel, and M. Bienengraeber
Xenon Preconditioning: The Role of Prosurvival Signaling, Mitochondrial Permeability Transition and Bioenergetics in Rats
Anesth. Analg., March 1, 2009; 108(3): 858 - 866.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
J. Dingley, C. Hobbs, J. Ferguson, J. Stone, and M. Thoresen
Xenon/Hypothermia Neuroprotection Regimes in Spontaneously Breathing Neonatal Rats After Hypoxic-Ischemic Insult: The Respiratory and Sedative Effects
Anesth. Analg., March 1, 2008; 106(3): 916 - 923.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J.-H. Baumert, M. Hein, K. E. Hecker, S. Satlow, J. Schnoor, and R. Rossaint
Autonomic cardiac control with xenon anaesthesia in patients at cardiovascular risk
Br. J. Anaesth., June 1, 2007; 98(6): 722 - 727.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
J. Dingley, J. Tooley, H. Porter, and M. Thoresen
Xenon Provides Short-Term Neuroprotection in Neonatal Rats When Administered After Hypoxia-Ischemia
Stroke, February 1, 2006; 37(2): 501 - 506.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J.-H. Baumert, K. E. Hecker, M. Hein, M. Reyle-Hahn, N. A. Horn, and R. Rossaint
Effects of xenon anaesthesia on the circulatory response to hypoventilation
Br. J. Anaesth., August 1, 2005; 95(2): 166 - 171.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J.-H. Baumert, K. E. Hecker, M. Hein, S. M. Reyle-Hahn, N. A. Horn, and R. Rossaint
Haemodynamic effects of haemorrhage during xenon anaesthesia in pigs
Br. J. Anaesth., June 1, 2005; 94(6): 727 - 732.
[Abstract] [Full Text] [PDF]

Home page
 Br Med BullHome page
R. D. Sanders, D. Ma, and M. Maze
Xenon: elemental anaesthesia in clinical practice
Br. Med. Bull., February 22, 2005; 71(1): 115 - 135.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
M. A. G. Hartlage, E. Berendes, H. Van Aken, M. Fobker, M. Theisen, and T. P. Weber
Xenon Improves Recovery from Myocardial Stunning in Chronically Instrumented Dogs
Anesth. Analg., September 1, 2004; 99(3): 655 - 664.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
B. Preckel and W. Schlack
Editorial III: Xenon--cardiovascularly inert?
Br. J. Anaesth., June 1, 2004; 92(6): 786 - 789.
[Full Text] [PDF]

Home page
 Br J AnaesthHome page
R. D. Sanders, N. P. Franks, and M. Maze
Xenon: no stranger to anaesthesia
Br. J. Anaesth., November 1, 2003; 91(5): 709 - 717.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.