Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (55)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Cortínez, L. I.
Right arrow Articles by Mur, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cortínez, L. I.
Right arrow Articles by Mur, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 2001, Vol. 87, No. 6 866-869
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Clinical Investigations

No clinical evidence of acute opioid tolerance after remifentanil-based anaesthesia

L. I. Cortínez, V. Brandes, H. R. Muñoz, M. E. Guerrero and M. Mur

Hospital Clínico Universidad Católica de Chile, Departamento de Anestesiología, Marcoleta 367, PO Box 114-D, Santiago, Chile*Corresponding author

We have prospectively assessed whether remifentanil-based anaesthesia is associated with clinically relevant acute opioid tolerance, expressed as greater postoperative pain scores or morphine consumption. Sixty patients undergoing elective gynaecological, non-laparoscopic, surgery were randomly assigned to receive remifentanil (group R, n=30) or sevoflurane (group S, n=30) based anaesthesia. Postoperative analgesia was provided with morphine through a patient-controlled infusion device. Mean (SD) remifentanil infusion rate in group R was 0.23 (0.10) µg kg–1 min–1 and mean inspired fraction of sevoflurane in group S was 1.75 (0.70)%. Mean (SD) cumulative morphine consumption during the first 24 postoperative hours was similar between groups: 28.0 (14.2) mg (group R) vs 28.6 (12.4) mg (group S). Pain scores, were also similar between groups during this period. These data do not support the development of acute opioid tolerance after remifentanil-based anaesthesia in this type of surgery.

Br J Anaesth 2001; 87: 866–9


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
L. A. Colvin and M. T. Fallon
Opioid-induced hyperalgesia: a clinical challenge
Br. J. Anaesth., February 1, 2010; 104(2): 125 - 127.
[Full Text] [PDF]

Home page
 Anesth. Analg.Home page
M. Pranevicius and O. Pranevicius
Non-Opioid Anesthesia with Esmolol Avoids Opioid-Induced Hyperalgesia and Reduces Fentanyl Requirement After Laparoscopy
Anesth. Analg., March 1, 2009; 108(3): 1048 - 1048.
[Full Text] [PDF]

Home page
 Br J AnaesthHome page
S. Eschertzhuber, M. Hohlrieder, C. Keller, E. Oswald, G. Kuehbacher, and P. Innerhofer
Comparison of high- and low-dose intrathecal morphine for spinal fusion in children
Br. J. Anaesth., April 1, 2008; 100(4): 538 - 543.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
V. Collard, G. Mistraletti, A. Taqi, J. F. Asenjo, L. S. Feldman, G. M. Fried, and F. Carli
Intraoperative Esmolol Infusion in the Absence of Opioids Spares Postoperative Fentanyl in Patients Undergoing Ambulatory Laparoscopic Cholecystectomy
Anesth. Analg., November 1, 2007; 105(5): 1255 - 1262.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
M. W. Crawford, C. Hickey, C. Zaarour, A. Howard, and B. Naser
Development of acute opioid tolerance during infusion of remifentanil for pediatric scoliosis surgery.
Anesth. Analg., June 1, 2006; 102(6): 1662 - 1667.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
M. Tirault, N. Derrode, D. Clevenot, D. Rolland, D. Fletcher, and B. Debaene
The Effect of Nefopam on Morphine Overconsumption Induced by Large-Dose Remifentanil During Propofol Anesthesia for Major Abdominal Surgery
Anesth. Analg., January 1, 2006; 102(1): 110 - 117.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
K. Rauf, A. Vohra, P. Fernandez-Jimenez, N. O'Keeffe, and M. Forrest
Remifentanil infusion in association with fentanyl-propofol anaesthesia in patients undergoing cardiac surgery: effects on morphine requirement and postoperative analgesia
Br. J. Anaesth., November 1, 2005; 95(5): 611 - 615.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
C. L. Beecroft, S. M. Enright, and H. A. O'Beirne
Remifentanil in the management of severe tetanus
Br. J. Anaesth., January 1, 2005; 94(1): 46 - 48.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
C. Hansen, I. Gilron, and M. Hong
The Effects of Intrathecal Gabapentin on Spinal Morphine Tolerance in the Rat Tail-Flick and Paw Pressure Tests
Anesth. Analg., October 1, 2004; 99(4): 1180 - 1184.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
D. D. Hood, R. Curry, and J. C. Eisenach
Intravenous Remifentanil Produces Withdrawal Hyperalgesia in Volunteers with Capsaicin-Induced Hyperalgesia
Anesth. Analg., September 1, 2003; 97(3): 810 - 815.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
V. De Castro, G. Godet, G. Mencia, M. Raux, and P. Coriat
Target-Controlled Infusion for Remifentanil in Vascular Patients Improves Hemodynamics and Decreases Remifentanil Requirement
Anesth. Analg., January 1, 2003; 96(1): 33 - 38.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.