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British Journal of Anaesthesia, 2001, Vol. 87, No. 5 691-698
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Clinical Investigations

Influence of equianaesthetic concentrations of nitrous oxide and isoflurane on regional cerebral blood flow, regional cerebral blood volume, and regional mean transit time in human volunteers

I. H. Lorenz1, C. Kolbitsch1, C. Hörmann1, T. J. Luger1, M. Schocke2, S. Felber2, F. Zschiegner1, M. Hinteregger1, C. Kremser2 and A. Benzer1

1Department of Anaesthesia and Intensive Care Medicine and 2Department of Magnetic Resonance Imaging, University of Innsbruck, Austria*Corresponding author: Department of Anaesthesia and Intensive Care Medicine, Leopold Franzens University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria

Nitrous oxide and isoflurane have cerebral vasodilatory effects. The use of isoflurane in neuroanaesthesia is widely accepted, whereas the use of nitrous oxide in neuroanaesthesia is still the subject of debate. In the present study, contrast-enhanced magnetic resonance (MR) perfusion measurement was used to compare the effects of 0.4 MAC nitrous oxide (n=9) and 0.4 MAC isoflurane (n=9) on regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV) and regional mean transit time (rMTT) in spontaneously breathing human volunteers. Nitrous oxide increased rCBF and rCBV in supratentorial regions more than did isoflurane. Isoflurane, by contrast, increased rCBF and rCBV in basal ganglia more than did nitrous oxide. An increased rMTT was caused by a relatively greater increase in rCBV than in rCBF supratentorially by isoflurane and infratentorially by nitrous oxide. In conclusion, nitrous oxide increases rCBF and rCBV predominantly in supratentorial grey matter, whereas isoflurane increases rCBF and rCBV predominantly in infratentorial grey matter.

Br J Anaesth 2001; 87: 691–8


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