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British Journal of Anaesthesia, 2001, Vol. 87, No. 2 286-288
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Short Communications

Influence of nitrous oxide on induction of anaesthesia with sevoflurane

H. O’Shea, S. Moultrie and G. B. Drummond

Department of Anaesthetics, Critical Care, and Pain Medicine, Royal Infirmary, Edinburgh EH3 9YW, UK*Corresponding author

{dagger}Published in abstract form: Br J Anaesth 2000; 85: 156P.

Nitrous oxide is often used during inhalation induction of anaesthesia with sevoflurane. Although the value of using nitrous oxide during inhalation induction with other volatile anaesthetics has been studied, the popularity of sevoflurane induction and the different characteristics of this agent make a study of the combination of nitrous oxide with this agent of interest. We compared induction times, oxygenation, and excitatory events during inhalation induction of anaesthesia using sevoflurane, with and without nitrous oxide. We studied 64 female patients, randomly allocated to receive inhalation induction of anaesthesia using sevoflurane with or without 50% nitrous oxide in the fresh gas, using a co-axial breathing system (Mapleson D) and a fresh gas flow rate of 3–6 litre min–1. Mean time to induction of anaesthesia (fall of an outstretched arm) was 102 s in both groups, but excitation (limb or head movement) was more frequent in those receiving nitrous oxide (10 patients) than in those receiving oxygen only (five patients) (P<0.05). Oxygenation was similar in both groups. We conclude that nitrous oxide confers no advantage when anaesthesia is induced with sevoflurane in this way.

Br J Anaesth 2001; 87: 286–8


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