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British Journal of Anaesthesia, 2001, Vol. 87, No. 2 280-283
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Short Communications

Influence of sepsis on minimum alveolar concentration of desflurane in a porcine model

B. Allaouchiche1, F. Duflo1, R. Debon1, J.-P. Tournadre1 and D. Chassard2

1Department of Anaesthesiology and Intensive Care, Hotel Dieu Hospital, Lyon, France. 2Department of Anaesthesiology and Intensive Care, Hotel Dieu Hospital, Lyon and Department of Research EA 18/96, Claude Bernard University, Lyon, France*Corresponding author

The effect of sepsis on the minimum alveolar concentration of desflurane (MACDES) in humans and other animals has not been reported previously. The aim of this study was to test the hypothesis that sepsis might alter MACDES in a normotensive septic porcine model. Twenty-four young healthy pigs were premedicated with ketamine 10 mg kg–1 i.m and then anaesthesia was established with propofol 3 mg kg–1 and the trachea was intubated. Baseline MACDES in each pig was evaluated by pinching with a haemostat applied for 1 min to a rear dewclaw. MACDES was determined by changing desflurane concentrations stepwise until purposeful movement appeared. Pigs were randomly assigned to two groups of 12 animals: the saline group received a 1 h i.v. infusion of saline solution while the sepsis group received a 1 h i.v. infusion of live Pseudomonas aeruginosa. Epinephrine and hydroxyethylstarch were used to maintain normotensive and normovolaemic haemodynamic status. In both groups, MACDES was evaluated 5 h after infusion. Significant increases in heart rate, cardiac output, mean pulmonary artery pressure and pulmonary vascular resistance occurred in the sepsis group. MACDES was 9.2% (95% confidence interval (CI) 6.8–10.6%) for the saline group and 6.7% (95% CI: 4.7–10.4) for the sepsis group (P<0.05). These data indicate that MACDES is significantly decreased in this normotensive hyperkinetic septic porcine model.

Br J Anaesth 2001; 86: 280–3


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