British Journal of Anaesthesia, 2001, Vol. 86, No. 6 859-868
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia
Perioperative bradycardia and asystole: relationship to vasovagal syncope and the Bezold–Jarisch reflex
1Sir Humphry Davy Department of Anaesthesia, St Michael’s Hospital, Southwell Street, Bristol BS2 8EG, UK. 2Department of Anaesthesia, Royal United Hospital, Combe Park, Bath BA1 3NG, UK*Corresponding author
Reflex cardiovascular depression with vasodilation and bradycardia has been variously termed vasovagal syncope, the Bezold–Jarisch reflex and neurocardiogenic syncope. The circulatory response changes from the normal maintenance of arterial pressure, to parasympathetic activation and sympathetic inhibition, causing hypotension. This change is triggered by reduced cardiac venous return as well as through affective mechanisms such as pain or fear. It is probably mediated in part via afferent nerves from the heart, but also by various non-cardiac baroreceptors which may become paradoxically active. This response may occur during regional anaesthesia, haemorrhage or supine inferior vena cava compression in pregnancy; these factors are additive when combined. In these circumstances hypotension may be more severe than that caused by bradycardia alone, because of unappreciated vasodilation. Treatment includes the restoration of venous return and correction of absolute blood volume deficits. Ephedrine is the most logical choice of single drug to correct the changes because of its combined action on the heart and peripheral blood vessels. Epinephrine must be used early in established cardiac arrest, especially after high regional anaesthesia.
Br J Anaesth 2001; 86: 859–68
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