British Journal of Anaesthesia, 2001, Vol. 86, No. 6 846-852
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia
Lidocaine reduces ischaemic but not reperfusion injury in isolated rat heart
1Physiologisches Institut I, Abteilung für Herz- und Kreislaufphysiologie, Heinrich-Heine-Universität Düsseldorf, Postfach 10 10 07, D-40001 Düsseldorf, Germany. 2Institut für Klinische Anaesthesiologie, Heinrich-Heine-Universität Düsseldorf, Germany*Corresponding author
The local anaesthetic lidocaine protects the myocardium in ischaemia–reperfusion situations. It is not known if this is the consequence of an anti-ischaemic effect or an effect on reperfusion injury. Therefore, we investigated the effect of two concentrations of lidocaine on myocardial ischaemia–reperfusion injury and on reperfusion injury alone. We used an isolated rat heart model where heart rate, ventricular volume and coronary flow were kept constant. Hearts underwent 45 min of low-flow ischaemia followed by 90 min reperfusion. Two groups received lidocaine 1.7 or 17 µg ml–1 starting 5 min before the onset of reperfusion. In two additional groups, lidocaine infusion started 5 min before low-flow ischaemia. In all groups, lidocaine administration was stopped after 15 min of reperfusion. One group served as an untreated control (n=11 in each group). Left ventricular developed pressure (LVDP) and total creatine kinase release (CKR) were measured. Lidocaine administration during ischaemia and reperfusion led to an improved recovery of LVDP during reperfusion (1.7 µg ml–1, 54 (SEM 10) mm Hg; 17 µg ml–1, 71 (9) mm Hg at 30 min of reperfusion; both significantly different from control (21 (4) mm Hg) (P<0.05)) and a reduced CKR (1.7 µg ml–1, 79 (13) IU; 17 µg ml–1, 52 (8) IU at 30 min of reperfusion; both significantly different from control (130 (8) IU (P<0.05)). Lidocaine given during early reperfusion only, affected neither LVDP during reperfusion (1.7 µg ml–1, 19 (6) mm Hg (P=1.0); 17 µg ml–1, 36 (8) mm Hg (P=0.46)) nor CKR (156 (21) IU (P=0.50) and 106 (14) IU (P=0.57)). We conclude that lidocaine protects the myocardium against ischaemic but not against reperfusion injury in the isolated rat heart.
Br J Anaesth 2001; 86: 846–52
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  H. Barthel, D. Ebel, J. Mullenheim, D. Obal, B. Preckel, and W. Schlack Effect of lidocaine on ischaemic preconditioning in isolated rat heart Br. J. Anaesth., November 1, 2004; 93(5): 698 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. S. Camara, Q. Chen, S. S. Rhodes, M. L. Riess, and D. F. Stowe Negative inotropic drugs alter indexes of cytosolic [Ca2+]-left ventricular pressure relationships after ischemia Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H667 - H680. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Harmon, W. Lan, K. Hahnenkamp, and C. W. Hoenemann Effects of Systemic Local Anesthetics on Perioperative Ischemia Reperfusion May Be Beneficial * Response Anesth. Analg., February 1, 2003; 96(2): 629 - 629. [Full Text] [PDF]
|
|