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British Journal of Anaesthesia, 2001, Vol. 86, No. 5 663-668
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Amrinone can accelerate the cooling rate of core temperature during deliberate mild hypothermia for neurosurgical procedures

S. Inoue1, M. Kawaguchi1, T. Sakamoto1, T. Iwata1, Y. Kawaraguchi1, H. Furuya1 and T. Sakaki2

1Department of Anaesthesiology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan. 2Department of Neurosurgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan*Corresponding author

We investigated the effects of i.v. amrinone on intraoperative changes of core temperature during deliberate mild hypothermia for neurosurgery. The patients in a control group (n=10) did not receive amrinone and patients in the amrinone group (n=10) received amrinone 5 µg kg–1 min–1 after a loading dose of 1.0 mg kg–1. Anaesthesia was maintained with nitrous oxide in oxygen, propofol and fentanyl. After the induction of anaesthesia, patients were cooled and tympanic membrane temperature was maintained at 34.5°C. After completion of the main surgical procedures, patients were rewarmed in the operating room. Tympanic membrane temperatures between 30 and 90 min after cooling were significantly lower in the amrinone group than in the control group. During cooling, the times taken to cool to 35°C and to the lowest temperature were significantly shorter in the amrinone group than in the control group. These results suggest that i.v. amrinone can accelerate the cooling rate of core temperature during deliberate mild hypothermia for neurosurgical procedures.

Br J Anaesth 2001; 86: 663–8


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T. Iwata, S. Inoue, M. Kawaguchi, M. Takahashi, T. Sakamoto, K. Kitaguchi, H. Furuya, and T. Sakaki
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