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British Journal of Anaesthesia, 2001, Vol. 86, No. 3 425-427
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Brief Communication

Effects of hypoxia and isoflurane on liver blood flow: the role of adenosine

S. H. Cray3, M. W. Crawford1, N. Khayyam1 and F. J. L. Carmichael2

1Department of Anaesthesia, The Hospital for Sick Children and 2Department of Pharmacology, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada 3Present address: Birmingham Children’s Hospital NHS Trust, Steelhouse Lane, Birmingham B4 6NL, UK*Corresponding author

Abstract

We investigated the role of endogenous adenosine in mediating the effects of hypoxia and isoflurane on portal tributary blood flow (PTBF) and hepatic arterial blood flow (HABF) in rats. Liver blood flows were determined using radiolabelled microspheres. Hypoxia resulting from the exposure of rats to an atmosphere containing 15% oxygen for 30 min decreased PTBF (23%) (P<0.05) and cardiac index (15%) (P<0.05), and increased HABF (78%) (P<0.05). Isoflurane (1.4 vol%) increased HABF in both normoxic and hypoxic conditions but did not affect PTBF. The adenosine receptor antagonist 8-phenyltheophylline attenuated the hypoxia-induced increase in HABF but did not affect that resulting from the administration of isoflurane. In conclusion, in contrast to the increase in HABF induced by hypoxia, that induced by isoflurane appears to be independent of endogenous adenosine.

Br J Anaesth 2000; 86: 425–7


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