Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (6)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Sakamoto, T.
Right arrow Articles by Furuya, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sakamoto, T.
Right arrow Articles by Furuya, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 2001, Vol. 86, No. 3 395-402
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Research

Suppressive effect of nitrous oxide on motor evoked potentials can be reversed by train stimulation in rabbits under ketamine/fentanyl anaesthesia, but not with additional propofol

T. Sakamoto, M. Kawaguchi, S. Inoue and H. Furuya

Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan*Corresponding author

Abstract

The effect of nitrous oxide on myogenic motor evoked potentials (MEPs) after multipulse stimulation is controversial. We investigated the effects of propofol in this paradigm. MEPs were elicited electrically by a single pulse and by trains of three and five pulses in rabbits anaesthetized with ketamine and fentanyl. Nitrous oxide 30–70% was given and MEPs were recorded. After washout of nitrous oxide, propofol was given as a bolus of 10 mg kg–1 followed by 0.8 (n=9) or 1.6 mg kg–1 min–1 (n=8) as a continuous infusion. Nitrous oxide was then readministered and MEPs were recorded. Without propofol, nitrous oxide significantly reduced the amplitude of MEPs dose-dependently, but this effect was reversed by multipulse stimulation. Administration of low-dose propofol enhanced nitrous oxide-induced suppression, and this effect was reversed by five-pulse stimulation. However, high-dose propofol produced a greater increase in suppression, such that even five-pulse stimulation did not overcome the suppression. The results suggest that the degree of reversal of nitrous oxide-induced MEP suppression produced by multipulse stimulation is affected by the administration of propofol.

Br J Anaesth 2001; 86: 395–402


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
Y. Yamamoto, M. Kawaguchi, M. Kakimoto, M. Takahashi, S. Inoue, T. Goto, and H. Furuya
The effects of xenon on myogenic motor evoked potentials in rabbits: a comparison with propofol and isoflurane.
Anesth. Analg., June 1, 2006; 102(6): 1715 - 1721.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
W. A. Janczewski and J. L. Feldman
Distinct rhythm generators for inspiration and expiration in the juvenile rat
J. Physiol., January 15, 2006; 570(2): 407 - 420.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
T. Sakamoto, M. Kawaguchi, M. Kakimoto, S. Inoue, M. Takahashi, and H. Furuya
The Effect of Hypothermia on Myogenic Motor-Evoked Potentials to Electrical Stimulation with a Single Pulse and a Train of Pulses Under Propofol/Ketamine/Fentanyl Anesthesia in Rabbits
Anesth. Analg., June 1, 2003; 96(6): 1692 - 1697.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
K.-M. Scheufler, C. Thees, J. Nadstawek, and J. Zentner
S(+)-Ketamine Attenuates Myogenic Motor-Evoked Potentials at or Distal to the Spinal {alpha}-Motoneuron
Anesth. Analg., January 1, 2003; 96(1): 238 - 244.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
M. Kakimoto, M. Kawaguchi, T. Sakamoto, S. Inoue, M. Takahashi, and H. Furuya
Effect of nitrous oxide on myogenic motor evoked potentials during hypothermia in rabbits anaesthetized with ketamine/fentanyl/propofol
Br. J. Anaesth., June 1, 2002; 88(6): 836 - 840.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.