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British Journal of Anaesthesia, 2001, Vol. 86, No. 2 183-188
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Gender differences in the pharmacokinetics of propofol in elderly patients during and after continuous infusion

J. Vuyk*, C. J. Oostwouder, A. A. Vletter, A. G. L. Burm and J. G. Bovill

Department of Anaesthesiology, Leiden University Medical Center (LUMC), PO Box 9600, 2300 RC Leiden, The Netherlands*Corresponding author

Differences in the pharmacokinetics of propofol between male and female patients during and after continuous infusion have not been described in detail in patients aged 65 yr and older. To increase our insight into the pharmacokinetics of propofol in this patient population and to obtain pharmacokinetic parameters applicable in target controlled infusion (TCI), the pharmacokinetics of propofol during and after continuous infusion were studied in 31 ASA class 1 and 2 patients, aged 65–91 yr, scheduled for general surgery. Patients received propofol 1.5 mg kg–1 i.v. in 1 min followed by 7 mg kg–1 h–1 until skin closure in the presence of a variable rate infusion of alfentanil during oxygen–air ventilation. On the basis of arterial blood samples that were taken up to 24 h post-infusion, the pharmacokinetics of propofol were evaluated in a two-stage manner. Multiple linear regression analysis was used to explore the effect of age, weight, gender and lean body mass as covariates. Gender significantly affected the pharmacokinetics of propofol. V3, Cl1 and Cl2 were significantly different between male and female patients, weight only affected Cl1. The pharmacokinetic parameters were: V1=4.88 litre, V2=24.50 litre, V3 (litre)=115+147xgender (gender: male=1, female=2), Cl1 (litre min–1)=–0.29+0.022x weight+0.22xgender, Cl2 (litre min–1)=2.84–0.65xgender (male=1, female=2), and Cl3=0.788 litre min–1.

Br J Anaesth 2001; 86: 183–8


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