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British Journal of Anaesthesia, 2001, Vol. 86, No. 1 38-43
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Effects of sevoflurane and propofol on pulmonary shunt fraction during one-lung ventilation for thoracic surgery

D. H. Beck, U. R. Doepfmer, C. Sinemus, A. Bloch, M. R. Schenk and W. J. Kox

Universitätsklinik Charité, Abteilung für Anaesthesiologie und operative Intensivmedizin, Schumannstrasse 20-21, D-10117 Berlin, Germany*Corresponding author

Forty patients requiring one-lung ventilation (OLV) for thoracic surgery were randomly assigned to receive propofol (4-6 mg kg–1 h–1) or sevoflurane (1 MAC) for maintenance of anaesthesia. Three sets of measurements were taken: (i) after 30 min of two-lung ventilation (TLV), (ii) after 30 min of one-lung ventilation (OLV-1) in the supine position and (iii) during OLV in the lateral position (OLV-2) with the chest open and before surgical manipulation of the lung. There were no differences between groups in patient characteristics or preoperative condition. Increases in shunt fraction during OLV-1 were 17.4% and 17.2% (P=0.94), those during OLV-2 were 18.3% and 16.5% (P=0.59) for the propofol and sevoflurane group, respectively. Cardiac index and other haemodynamic and respiratory variables were similar for the two groups. We conclude that inhibition of hypoxic pulmonary vasoconstriction by sevoflurane may only account for small increases in shunt fraction and that much of the overall shunt fraction during OLV has other causes.

Br J Anaesth 2001; 86: 38–43


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