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British Journal of Anaesthesia, 2001, Vol. 86, No. 1 29-37
© 2001 The Board of Management and Trustees of the British Journal of Anaesthesia

Model-based administration of inhalation anaesthesia. 2. Exploring the system model

J. G. C. Lerou* and L. H. D. J. Booij

Institute for Anaesthesiology, University of Nijmegen, Geert Grooteplein 10, 6500 HB Nijmegen, The Netherlands *Corresponding author

We explored our model by displaying its new capabilities, testing its sensitivity to variations in input data and illustrating its use. Its multiple-gas character allows simulation of the mechanisms governing concentration and second gas effects. Simulating the volume of a standing bellows makes it possible to test algorithms for automated closed-circuit anaesthesia. Using desflurane, the model’s sensitivity to changes in blood/gas partition coefficient (range 0.42–0.576), cardiac output and minute ventilation was analysed. The model was very sensitive to changes in blood solubility; other results agreed with those reported previously. An alveolar isoflurane tension of 1% atm was rapidly attained and maintained, even using 0.5 litres min–1 of fresh gas, when isoflurane was ‘co-administered’ through a vaporizer set to 3.5 vol% and a single aliquot (1.25 ml liquid) injected into the expiratory limb. As a result of its credibility and capabilities, the model is to be tested in the clinical setting.

Br J Anaesth 2001; 86: 29–37


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