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British Journal of Anaesthesia, 2000, Vol. 85, No. 5 785-787
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Brief Communication

Effect of remifentanil compared with fentanyl on intraocular pressure after succinylcholine and tracheal intubation{dagger}

H.-P. Ng1, F.-G. Chen1,*, S.-M. Yeong1, E. Wong2 and P. Chew2

Departments of 1Anaesthesia and 2Ophthalmology, National University Hospital, Singapore, 5 Lower Kent Ridge Road, Singapore 119074

{dagger}Presented in part at the International Anaesthesia Research Society, 2000.

Abstract

Rapid sequence induction using succinylcholine is associated with an increase in intraocular pressure (IOP). This may lead to loss of ocular contents in open globe injuries. No method has previously been shown to prevent this increase in IOP. We investigated whether remifentanil, an ultra-short-acting opioid, could attenuate this increase in IOP during rapid sequence induction of anaesthesia. Forty-five patients were randomized blindly to receive remifentanil 1 µg kg–1, fentanyl 2 µg kg–1 or placebo 1 min before thiopental, succinylcholine and tracheal intubation. IOP and haemodynamic variables were measured before, 1 min after the test solution, 30 s after thiopental, 30 s after succinylcholine, immediately after intubation and then every 3 min for 9 min. Remifentanil obtunded the increase in IOP after succinylcholine and intubation, so it could be suitable for use in open globe injuries.

Br J Anaesth 2000; 85: 785–7

Footnotes

* Corresponding author


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