British Journal of Anaesthesia, 2000, Vol. 85, No. 5 717-723
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia
Urinary, biliary and faecal excretion of rocuronium in humans
1Research Group for Experimental Anaesthesiology and Clinical Pharmacology, Department of Anaesthesiology, University Hospital, Hanzeplein 1, 9713 GZ Groningen, The Netherlands. 2Department of Anaesthesiology and Intensive Care, Karolinska Hospital and Institute, Stockholm, Sweden. 3Department of Anaesthetics and Intensive Care Medicine, The Queen’s University, Belfast, UK. 4Organon Teknika, Boxtel, The Netherlands
The excretion of rocuronium and its potential metabolites was studied in 38 anaesthetized patients, ASA I–III and 21–69 yr old. Rocuronium bromide was administered as an i.v. bolus dose of 0.3 or 0.9 mg kg–1. In Part A of the study, the excretion into urine and bile, and the liver content were studied. Plasma kinetics (n=19) were similar to those reported previously. Urinary recovery within 48 h after administration was 26 (8)% (mean (SD)) (n=8) of the dose. In bile obtained from T-drains, the recovery within 48 h was 7 (6)% (n=11). The rocuronium concentration in bile declined bi-exponentially, with half-lives of 2.3 (0.7) and 16 (11) h respectively (n=6). In three patients from whom stoma fluid was collected, the amount of rocuronium recovered ranged from 0.04 to 12.0% of the dose. In liver tissue obtained from four patients undergoing hemihepatectomy, the estimated amount of rocuronium at 2–5 h after administration ranged between 6.3 and 13.2% (n=4). In the second part of the study (Part B), urine and faeces were collected over 4–8 days and the recovery was 27 (13)% and 31 (23)% of the dose respectively (n=10). In most samples, irrespective of the type of biological material, only small amounts of the metabolite 17-desacetyl-rocuronium was found. The results demonstrate that rocuronium is taken up by the liver and excreted into bile in high concentrations. The faecal and urinary excretion of unchanged rocuronium are the major routes of rocuronium elimination.
Br J Anaesth 2000; 85: 717–23
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Ezzine and F. Varin Interstitial muscle concentrations of rocuronium under steady-state conditions in anaesthetized dogs: actual versus predicted values Br. J. Anaesth., January 1, 2005; 94(1): 49 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gao, I. Ramzan, and B. Baker Rocuronium plasma concentrations during three phases of liver transplantation: relationship with early postoperative graft liver function{dagger}{ddagger} Br. J. Anaesth., June 1, 2002; 88(6): 764 - 770. [Abstract] [Full Text] [PDF]
|
|