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British Journal of Anaesthesia, 2000, Vol. 85, No. 4 620-623
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Lack of pre-emptive analgesic effects of local anaesthetics on neuropathic pain

S. Abdi1,*, D. H. Lee2, S. K. Park2 and J. M. Chung2

1Department of Anesthesiology and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. 2Marine Biomedical Institute and Departments of Anatomy, Neurosciences, Physiology, and Biophysics, The University of Texas Medical Branch, Galveston, TX 77555, USA

We investigated the significance of pre-emptive analgesia using a well-known model of neuropathic pain in rats. Lignocaine, bupivacaine or saline was applied locally to the left L5–L6 spinal nerve before or 4 days after nerve injury. Mechanical allodynia was then evaluated before and after injury. Pre- and post-injury treatment with local anaesthetics both resulted in a two- to threefold increase in the pain threshold, as manifested by a significant increase in von Frey measurements. However, this effect lasted only 24 h. Our study in rats questions the beneficial effect of a single dose of local anaesthetic as pre-emptive analgesia.

Br J Anaesth 2000; 85: 620–3.

* Corresponding author: Department of Anesthesia and Critical Care, Clinics 3, Massachusetts General Hospital, Harvard Medical School, 32 Fruit Street, Boston, MA 02114, USA


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