Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow An erratum has been published
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (15)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Hahn, T. W.
Right arrow Articles by Rasmussen, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hahn, T. W.
Right arrow Articles by Rasmussen, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, 2000, Vol. 85, No. 4 512-519
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Pharmacokinetics of rectal paracetamol after repeated dosing in children

T. W. Hahn1,*, S. W. Henneberg2, R. J. Holm-Knudsen2, K. Eriksen2, S. N. Rasmussen3 and M. Rasmussen1

1Department of Pharmaceutics and 3Department of Pharmacology, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen, Denmark. 2Department of Anaesthesiology, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark

Twenty-three children(aged between 9 weeks and 11 yr) were given paracetamol suppositories 25 mgkg–1 every 6 h (maximum 5 days) after major surgery andserum and saliva concentrations were measured. There was a good correlation(r=0.91, P<0.05) between saliva andserum concentrations. A one-compartment linear model withfirst-order elimination and absorption and lag-time was fitted tothe data (ADAPT II). At steady state, the mean (SD)concentration was 15.2 (6.8) mg litre–1. Mean (SD) time to reach 90% of the steady state concentrationwas 11.4 (8.6) h. Body weight, age and body surface area were wellcorrelated (P<0.05) with clearance and apparent volume ofdistribution. There was no evidence of accumulation leading tosupratherapeutic concentrations during this dosing schedule for a mean ofapproximately 2–3 days.

Br J Anaesth 2000; 85: 512–9

* Corresponding author


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Anesth. Analg.Home page
A. Hiller, O. A. Meretoja, R. Korpela, S. Piiparinen, and T. Taivainen
The analgesic efficacy of acetaminophen, ketoprofen, or their combination for pediatric surgical patients having soft tissue or orthopedic procedures.
Anesth. Analg., May 1, 2006; 102(5): 1365 - 1371.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Pharmacy PracticeHome page
P. C. Walker and D. S. Wagner
Treatment of Pain in Pediatric Patients
Journal of Pharmacy Practice, August 1, 2003; 16(4): 261 - 275.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.