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British Journal of Anaesthesia, 2000, Vol. 85, No. 3 460-462
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Spasmolytic effects of prostaglandin E1 on serotonin-induced bronchoconstriction and pulmonary hypertension in dogs

Y. Hashimoto, K. Hirota, H. Yoshioka, E. Hashiba, T. Kudo, H. Ishihara and A. Matsuki

Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036–8562, Japan*Corresponding author

In this study, we simultaneously evaluated the spasmolytic effects of prostaglandin E1 (PGE1) on serotonin-induced bronchoconstriction and pulmonary hypertension. Eleven mongrel dogs (8–12 kg) anaesthetized with pentobarbital were assigned to two groups: saline (n=4) and PGE1 (n=7). Bronchoconstriction and pulmonary hypertension were elicited with serotonin 10 µg kg–1 + 1 mg kg–1 h–1 and assessed as the percentage change in bronchial cross-sectional area (BCA) measured by bronchoscopy and pulmonary vascular resistance (PVR), respectively. Thirty minutes after starting the serotonin infusion, saline or PGE1 0 (saline), 0.01, 0.1, 1.0 or 10 µg kg–1 i.v. was given. %BCA and %PVR (basal=100%) were assessed before and 30 min after serotonin, and 30 and 60 min after saline (saline group) or 5 min after each dose of PGE1 (PGE1 group). In the saline group, pulmonary hypertension and bronchoconstriction were stable. In the PGE1 group, PGE1 at >=0.1 µg kg–1 significantly decreased %BCA and 10 µg kg–1 almost fully reversed the constriction (from mean (SEM) 56.2% (4.9%) to 94.4% (3.7%)). %PVR was significantly decreased at 10 µg kg–1 (from 230% (24%) to 176% (11%)) only. We suggest that PGE1 may produce bronchodilation rather than pulmonary vasodilation.

Br J Anaesth 2000; 85: 460–2


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