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British Journal of Anaesthesia, 2000, Vol. 85, No. 3 431-439
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Somatosensory evoked potentials for closed-loop control of anaesthetic depth using propofol in the urethane-anaesthetized rat

A. Angel1,*, R. H. Arnott1,3, D. A. Linkens2 and C. H. Ting1,2,4

1Centre for Research into Anaesthetic Mechanisms, Department of Biomedical Science, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK. 2Department of Automatic Control and Systems Engineering, Amy Johnson Building, The University of Sheffield, Mappin Street, Sheffield S1 3JD, UK 3MRC Institute of Hearing Research, University Park, Nottingham NG7 2RD, UK and 487, Hsiding, Taihsi, Yunlin 63608, Taiwan

Primary somatosensory cortical mass responses have been shown to exhibit dose-dependent changes in latency when general anaesthetics are administered. Here we describe a system in which the latency of evoked responses was measured automatically in real time in five animals. Latency changes were used to operate a closed-loop control of propofol delivery by intravenous infusion. The system attempted to induce and maintain a 1 ms increase in evoked response latency; this was reversed when infusion was discontinued. Allowing for the rapid and large biological fluctuations in the evoked response, this was achieved successfully. The system maintained a mean increase in latency of 1.27 (SD 0.42) ms. The mean statistical dispersion index of data obtained during the controlled period was 1.23 (0.3); in an ideal controllable system it approximates to 1. Such a system may provide a means for the automatic delivery of anaesthetics.

Br J Anaesth 2000; 85: 431–9

* Corresponding author. Present address: MRC Institute of Hearing Research, University Park, Nottingham NG7 2RD, UK and 87, Hsiding, Taihsi, Yunlin 63608, Taiwan


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