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British Journal of Anaesthesia, 2000, Vol. 85, No. 2 195-198
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Serum mitochondrial aspartate transaminase activity after isoflurane or halothane anaesthesia

J. R. Darling*,1, P. C. Sharpe2, E. K. Stiby1, J. A. McAteer1, G. P. R. Archbold2 and K. R. Milligan1

1Department of Anaesthesia, Musgrave Park Hospital, Belfast BT9 7JB, UK. 2Department of Clinical Chemistry, Belfast City Hospital, Belfast BT9 7AB, UK*Corresponding author

We examined the effect of halothane or isoflurane anaesthesia on hepatic function in 30 ASA I–III patients aged 18–70 yr undergoing lumbar discectomy. Hepatic function was assessed before anaesthesia, at the end of surgery, and at 3, 6, 24 and 48 h after surgery using routine enzyme tests of hepatic function and mitochondrial aspartate transaminase (mAST) activity. Although serum mAST activities increased after surgery in both groups of patients, these increases were statistically significantly greater in the group that received halothane. The groups were similar with regard to other tests of hepatic function. Calculation of the ratio of serum enzyme activities compared to baseline values suggested that mAST is a sensitive marker of anaesthetic-induced hepatic injury.

Br J Anaesth 2000; 85: 195–8


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