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British Journal of Anaesthesia, 2000, Vol. 84, No. 6 763-766
© 2000 Oxford University Press

Clinical Investigation

Serum myoglobin and creatine kinase following surgery

A. S. Laurence1

1 Royal Preston Hospital, Preston PR2 4HT, UK

Abstract

Serum myoglobin (by radioimmunoassay) and creatine kinase were measured for up to 7 days in 30 patients following surgical procedures, including total hip replacement and bilateral subcostal abdominal incisions. Serum myoglobin reached a maximum of 1390 µg litre–1 (median 345 µg litre–1 for major surgery patients) on the first postoperative day but levels were still elevated by day 7 in some patients. Creatine kinase reached a maximum of 1339 i.u. litre–1 at day 2 (median 422 i.u. litre–1 for major surgery patients), generally peaking 1 day after myoglobin in individual patients. These values may have significance when investigating a suspicion of coincident perioperative events such as myocardial infarction or malignant hyperthermia.


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