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British Journal of Anaesthesia, 2000, Vol. 84, No. 5 638-639
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Short Communication

Cp50 of propofol with and without nitrous oxide 67%

P. C. Stuart1,2, S. M. Stott2, A. Millar1, G. N. C. Kenny1 and D. Russell1,2

1 Department of Anaesthesia, University of Glasgow, Glasgow G31 2ER, UK.
2 Department of Anaesthesia, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, UK

D. Russell, Department of Anaesthesia, University of Glasgow, Glasgow G31 2ER, UK.

The target concentration of propofol required to prevent response to surgical incision was determined in 60 unpremedicated ASA I or II patients, who breathed either oxygen-enriched air or nitrous oxide 67% in oxygen. Propofol was infused using a target-controlled infusion system incorporating the standard ‘Diprifusor’ pharmacokinetic model, with the target concentration for each patient decided by up/down sequential allocation. Presence or absence of movement in response to a groin incision was determined by the surgeon. The calculated blood concentration at which 50% of patients responded (Cp50), determined by probit analysis, was 6.8 µg ml–1 for patients who breathed oxygen-enriched air and 4.9 µg ml–1 for those who breathed nitrous oxide 67% in oxygen.


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