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British Journal of Anaesthesia, 2000, Vol. 84, No. 5 633-635
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Short Communication

Effect of anaesthesia on the cardiac response to intravenous adenosine

N. J. Morgan-Hughes1 and K. M. Sherry1

1 Department of Anaesthesia, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK

K. M. Sherry, Department of Anaesthesia, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK

The cardiac response to intravenous adenosine 112 µg kg–1] was studied in 16 patients scheduled for coronary artery bypass surgery before and during anaesthesia with 1% end-tidal isoflurane and fentanyl 10 µg kg–1. Mean time from injection to onset of adenosine-induced PR prolongation was significantly greater during anaesthesia (12.8 ( 5) vs 9.9 (3) s, P=0.032). Atrioventricular block (assessed by the total number of non-conducted P waves) was significantly less during anaesthesia (12 vs 27, P=0.016). We conclude that anaesthesia including 1% isoflurane and fentanyl 10 µg kg–1 delays the onset and reduces the magnitude of adenosine-induced atrioventricular block.


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