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British Journal of Anaesthesia, 2000, Vol. 84, No. 5 631-633
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Short Communication

Effects of isoflurane, sevoflurane and propofol anaesthesia on jugular venous oxygen saturation in patients undergoing coronary artery bypass surgery

Koichiroh Nandate1,2, Alain Vuylsteke2, Indrek Ratsep2, Souad Messahel1, Amo Oduro-Dominah2, David K. Menon1 and Basil F. Matta3

1 Department of Anaesthesia, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK.
2 Department of Anaesthesia, Papworth Hospital, Papworth Everand, Cambridge CB3 8RE, UK.
3 Department of Anaesthesia, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK

Basil F. Matta, Department of Anaesthesia, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK

We investigated the effect of sevoflurane, isoflurane and propofol on jugular venous bulb oxygen saturation (SjO2) in 21 patients undergoing coronary artery bypass graft surgery (CABG) during and after normothermic cardiopulmonary bypass (CPB). Patients received a standardized anaesthetic consisting of fentanyl, midazolam and were then randomly allocated to receive either isoflurane, sevoflurane or propofol for maintenance. SjO2 values were significantly lower than baseline 1 h after CPB in the propofol but not the isoflurane or the sevoflurane groups. Furthermore, SjO2 values were significantly higher during CPB in the isoflurane group (P=0.0081) and significantly lower 6 h after CPB in the sevoflurane group (P=0.0447) when compared to the propofol group. We conclude that jugular venous desaturation during and after normothermic CPB is more likely during propofol anaesthesia.


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