British Journal of Anaesthesia, 2000, Vol. 84, No. 5 608-614
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia
Laboratory Investigation |
Fentanyl reduces infarction but not stunning via 
-opioid receptors and protein kinase C in rats
1 Nuffield Department of Anaesthetics, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
R. Kato, Nuffield Department of Anaesthetics, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
Langendorff rat hearts were used (i) to examine whether fentanyl reduces stunning, infarction or both, and (ii) to investigate if this protection is mediated by 
-opioid receptors and/or protein kinase C (PKC). In the stunning study, hearts were subjected to global ischaemia (20 min) and reperfusion. This did not produce infarction. Postischaemic mechanical function was measured in hearts treated with or without fentanyl (740 n
). Fentanyl did not affect postischaemic mechanical function. In the infarction study, the left anterior descending coronary artery was occluded for 35 min and infarct size was assessed by triphenyltetrazolium chloride staining. Hearts in the control group exhibited an infarct zone/area at risk (I/R) of 39 (
5)%, whereas the I/R for the fentanyl group was 13 (2)%. When the hearts were treated with a -opioid receptor antagonist (naltrindole 1 n) or a PKC inhibitor (chelerythrine 2 µ), the effect of fentanyl was abolished, with I/R of 37 (1) and 36 (2)% respectively. In our model, we conclude that fentanyl protects against infarction but not against stunning, and that the limitation of ischaemic injury is mediated by both -opioid receptors and PKC.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. R. Gross, A. K. Hsu, and G. J. Gross Acute Methadone Treatment Reduces Myocardial Infarct Size via the {delta}-Opioid Receptor in Rats During Reperfusion Anesth. Analg., November 1, 2009; 109(5): 1395 - 1402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Lessa and E. Tibirica Pharmacologic Evidence for the Involvement of Central and Peripheral Opioid Receptors in the Cardioprotective Effects of Fentanyl Anesth. Analg., October 1, 2006; 103(4): 815 - 821. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. Gross and G. J. Gross Ligand triggers of classical preconditioning and postconditioning Cardiovasc Res, May 1, 2006; 70(2): 212 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Bovill Intravenous Anesthesia for the Patient with Left Ventricular Dysfunction Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2006; 10(1): 43 - 48. [Abstract] [PDF]
|
|
|
|
 |
|
 E. R. Gross, J. N. Peart, A. K. Hsu, J. A. Auchampach, and G. J. Gross Extending the cardioprotective window using a novel {delta}-opioid agonist fentanyl isothiocyanate via the PI3-kinase pathway Am J Physiol Heart Circ Physiol, June 1, 2005; 288(6): H2744 - H2749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kuzume, K. Kuzume, Z. Cao, L. Liu, and D. M. Van Winkle Long-term infusion of Met5-enkephalin fails to protect murine hearts against ischemia-reperfusion injury Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1717 - H1723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. G. Hartlage, E. Berendes, H. Van Aken, M. Fobker, M. Theisen, and T. P. Weber Xenon Improves Recovery from Myocardial Stunning in Chronically Instrumented Dogs Anesth. Analg., September 1, 2004; 99(3): 655 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zaugg, M. C. Schaub, and P. Foex Myocardial injury and its prevention in the perioperative setting Br. J. Anaesth., July 1, 2004; 93(1): 21 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kuzume, R. A. Wolff, K. Amakawa, K. Kuzume, and D. M. Van Winkle Sustained exogenous administration of Met5-enkephalin protects against infarction in vivo Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2463 - H2470. [Abstract] [Full Text] [PDF]
|
|