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British Journal of Anaesthesia, 2000, Vol. 84, No. 5 596-569
© 2000 The Board of Management and Trustees of the British Journal of Anaesthesia

Laboratory Investigation

Chemiluminescence underestimates nitric oxide concentration in the presence of potent inhalation anaesthetics

R. Liu1, Y. Ishibe1, N. Okazaki1 and K. Kimura2

1 Department of Anaesthesiology and Reanimatology, Tottori University Faculty of Medicine, Tottori 683-8504, Yonago, Japan
2 Department of Biochemistry, Tottori University Faculty of Medicine, Tottori 683-8504, Yonago, Japan

Y.Ishibe, Department of Anaesthesiology and Reanimatology, Tottori University Faculty of Medicine, Tottori 683-8504, Yonago, Japan

We investigated the effect of potent inhalation anaesthetics on nitric oxide (NO) concentration measured by the chemiluminescence method. We found that the NO concentration was increasingly underestimated with increasing concentrations of halothane, isoflurane, enflurane and sevoflurane (r2=0.918–0.997, P<0.01). Statistical analysis showed that the four inhalation agents at the same concentration produced a similar error in the measured NO concentration. In the presence of a fixed concentration of sevoflurane (5.0%), isoflurane (5.2%), enflurane (4.5%) or halothane (6.1%), the rate of reduction in the measured NO concentration increased in proportion to the NO concentration (r2=0.909–0.982, P<0.01). No direct chemical interaction between the potent inhalation agents and NO was detected by gas chromatography–mass spectrometry. We conclude that NO concentration can be underestimated when measured by the chemiluminescence method in the presence of potent inhalation agents. This underestimation may result from emission absorption and/or the quenching phenomenon, but is not attributable to a chemical reaction between the inhalation agent and NO.


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