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British Journal of Anaesthesia, Vol 84, Issue 4 505-507, Copyright © 2000 by Oxford University Press

ARTICLES

Intratracheal recombinant human deoxyribonuclease in acute life- threatening asthma refractory to conventional treatment

A Patel, E Harrison, A Durward and IA Murdoch
Department of Paediatric Intensive Care, Guy's Hospital, London, UK.

Recombinant human deoxyribonuclease (rhDNase) is a mucolytic agent used to relieve peripheral airway obstruction in patients with cystic fibrosis. We report dramatic sustained improvement following the intratracheal administration of rhDNase to a 3-yr-old boy with acute life-threatening asthma in whom 48 h of aggressive therapy had failed.
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