British Journal of Anaesthesia, Vol 84, Issue 4 489-490, Copyright © 2000 by Oxford University Press
AN Strachan and ND Edwards
The effect of the combination of opiates and hypnotics on bispectral index
(BIS) is unclear. This double-blind placebo-controlled trial investigated
the effect on BIS and sedation of different infusion doses of remifentanil
combined with a steady infusion of propofol. Forty patients initially
received a target-controlled infusion of propofol 2 micrograms ml-1 for 15
min. They were then randomized to receive either placebo, 0.01, 0.05 or 0.1
microgram kg-1 min-1 remifentanil for a further 15 min. We found a
significant correlation between the dose of remifentanil and the change of
BIS after 15 min of infusion. The correlation between all the sedation
scores and their corresponding BIS was also significant. We concluded that
remifentanil, in combination with propofol, reduces BIS when used for
sedation.
ARTICLES
Randomized placebo-controlled trial to assess the effect of remifentanil and propofol on bispectral index and sedation
University Department of Anaesthesia, Northern General Hospital, Sheffield, UK.
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