Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-Letters: Submit a response to the article
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (16)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Wissing, H.
Right arrow Articles by Fuhr, U.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wissing, H.
Right arrow Articles by Fuhr, U.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

British Journal of Anaesthesia, Vol 84, Issue 4 443-449, Copyright © 2000 by Oxford University Press

ARTICLES

Pharmacokinetics of inhaled anaesthetics in a clinical setting: comparison of desflurane, isoflurane and sevoflurane

H Wissing, I Kuhn, S Rietbrock and U Fuhr
Department of Anaesthesiology, Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany.

The pharmacokinetic characteristics of desflurane, isoflurane and sevoflurane (16 patients for each anaesthetic) were estimated from measurements of inspired and end-expired agent concentrations and ventilation, obtained during routine anaesthesia in patients undergoing maxillofacial surgery (mean age 38 yr, duration of anaesthesia approximately 2 h). A two-compartment model described the data adequately. Although isoflurane and sevoflurane have almost the same tissue/blood partition coefficients, significant differences between substances were observed for the peripheral volume of distribution (medians and ranges: desflurane, 612 (343-1850) mlvapour kgbw-1; isoflurane, 4112 (1472-9396) mlvapour kgbw-1; sevoflurane, 1634 (762- 8843) mlvapour kgbw-1) and the transport clearance from the central to the peripheral compartment (desflurane, 7.0 (4.4-11.1) mlvapour kgbw-1 min-1; isoflurane, 30.7 (15.9-38.7) mlvapour kgbw-1 min-1; sevoflurane, 13.0 (9.8-22.4) mlvapour kgbw-1 min-1). Thus, during clinical anaesthesia the important characteristics of the compounds could be obtained and compared between substances from simple data.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
L. La Colla, A. Albertin, G. La Colla, and A. Mangano
Faster wash-out and recovery for desflurane vs sevoflurane in morbidly obese patients when no premedication is used
Br. J. Anaesth., September 1, 2007; 99(3): 353 - 358.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
Y. Jiang, J. C. Wain, A. W. Chang, W. M. Zapol, and Z. Xie
Differential changes of alveolar gas concentrations during anesthetic induction of a patient with an absent right pulmonary artery.
Anesth. Analg., August 1, 2006; 103(2): 312 - 5, table of contents.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
A. Vesely, J. A. Fisher, N. Sasano, D. Preiss, R. Somogyi, H. El-Beheiry, A. Prabhu, and H. Sasano
Isocapnic hyperpnoea accelerates recovery from isoflurane anaesthesia
Br. J. Anaesth., December 1, 2003; 91(6): 787 - 792.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
R. R. Kennedy, R. A. French, and C. Spencer
Predictive Accuracy of a Model of Volatile Anesthetic Uptake
Anesth. Analg., December 1, 2002; 95(6): 1616 - 1621.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J. G. C. Lerou and L. H. D. J. Booij
Model-based administration of inhalation anaesthesia. 3. Validating the system model
Br. J. Anaesth., January 1, 2002; 88(1): 24 - 37.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.